PMID- 28429425
OWN - NLM
STAT- MEDLINE
DCOM- 20180315
LR  - 20180315
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 45
IP  - 7
DP  - 2017 Jul
TI  - Accuracy of cytology in sub typing non small cell lung carcinomas.
PG  - 598-603
LID - 10.1002/dc.23730 [doi]
AB  - BACKGROUND: Sub typing of non small cell lung carcinoma (NSCLC) has an important 
      task in the era of molecular and targeted therapies. Differentiating between 
      squamous cell carcinoma (SQCC) and adenocarcinoma (ADC) is challenging when 
      limited material is available in lung carcinoma. We investigated the accuracy and 
      feasibility of sub typing NSCLCs in cytology and small biopsy material. METHODS: 
      Concurrent cytology and biopsy material obtained in a single CT- guided procedure 
      in lung carcinoma over a year period retrospectively. Both materials were 
      individually sub typed and analyzed. Immunohistochemistry (IHC) was performed. 
      Accuracy was determined by comparing the results with IHC. RESULTS: Total 107 of 
      126 cases of NSCLCs were included for analysis, where both cytology and biopsy 
      material were adequate for interpretation. FNAC allowed tumor typing in 83 
      (77.6%) cases; 36 (33.6%) were ADC, 47 (43.9%) cases were SQCC and 24 (22.4%) 
      cases diagnosed as Non-small cell carcinoma not otherwise specified (NSCLC-NOS). 
      In biopsy, 86 cases (80.4%) were typed, among which 34 (31.8%) were ADC, 52 
      (48.6%) were SQCC and 21 (19.6%) were of NSCLC-NOS type. The result of Chi-square 
      index was significant. With the aid of IHC, NSCLC-NOS reduced from 14 (13%) cases 
      to 2 (1.9%) cases. CONCLUSION: Cytology and small biopsy specimens achieved 
      comparable specificity and accuracy in sub-typing NSCLC and optimal results were 
      obtain when findings from both modalities combine. The advantage of paired 
      specimens is to maximize overall diagnostic yield and the remaining material will 
      be available for ancillary technique like IHC or for molecular testing. Diagn. 
      Cytopathol. 2017;45:598-603. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Patel, Trupti S
AU  - Patel TS
AUID- ORCID: 0000-0002-5887-2042
AD  - Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, 
      Gujarat, India.
FAU - Shah, Majal G
AU  - Shah MG
AD  - Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, 
      Gujarat, India.
FAU - Gandhi, Jahnavi S
AU  - Gandhi JS
AD  - Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, 
      Gujarat, India.
FAU - Patel, Pratik
AU  - Patel P
AD  - Department of Pathology, Gujarat Cancer and Research Institute, Ahmedabad, 
      Gujarat, India.
LA  - eng
PT  - Journal Article
DEP - 20170421
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Adenocarcinoma/*diagnosis/pathology/surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Fine-Needle/instrumentation/*methods
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/pathology/surgery
MH  - Carcinoma, Squamous Cell/*diagnosis/pathology/surgery
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Image-Guided Biopsy
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*diagnosis/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - NSCLC
OT  - cytology
OT  - lung
OT  - small biopsy
OT  - sub type
EDAT- 2017/04/22 06:00
MHDA- 2018/03/16 06:00
CRDT- 2017/04/22 06:00
PHST- 2016/12/26 00:00 [received]
PHST- 2017/03/12 00:00 [revised]
PHST- 2017/04/03 00:00 [accepted]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2018/03/16 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
AID - 10.1002/dc.23730 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2017 Jul;45(7):598-603. doi: 10.1002/dc.23730. Epub 2017 Apr 
      21.