PMID- 28429995
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20220318
IS  - 1477-2817 (Electronic)
IS  - 1477-2817 (Linking)
VI  - 71
IP  - 3
DP  - 2017 Jun
TI  - New insights into the role of dietary spermine on inflammation, immune function 
      and related-signalling molecules in the thymus and spleen of piglets.
PG  - 175-191
LID - 10.1080/1745039X.2017.1314610 [doi]
AB  - This study aimed to determine the effects of dietary spermine supplementation on 
      the inflammatory response and immune function of the thymus and spleen in 
      piglets. Eighty suckling piglets were randomly assigned to receive adequate 
      nutrients supplemented with spermine (0.4 mmol/kg body weight) or restricted 
      nutrient intake supplemented with normal saline for 7 h or 3, 6 and 9 days in 
      pairs. Regardless of treatment time, spermine supplementation decreased 
      (p < 0.05, compared with the controls) the following: (1) tumour necrosis factor 
      alpha (TNF-alpha), interleukin (IL)-1beta, 2 and 6, and interferon (IFN)-gamma levels in serum; 
      (2) gene expression of cluster of differentiation 8 and integrin beta-2 in the 
      thymus and spleen and the lymphocyte function-associated antigen 1 in the thymus; 
      (3) mRNA levels of TNF-alpha, IL 1beta, 2, 6, and 12, IFN-gamma and inducible nitric oxide 
      synthase in the thymus and spleen, as well as IL-8 in the spleen; and (4) 
      eukaryotic IF4E-binding protein 1, Janus kinase 2, signal transducer and 
      activator of transcription 3, and nuclear factor-kappa B P65 gene transcriptions 
      in the thymus and spleen. By contrast, spermine supplementation increased 
      (p < 0.05) the following: (1) immunoglobulin M, IL-10, and transforming growth 
      factor beta1 gene expression, as well as (2) relative mRNA levels of mammalian 
      target of rapamycin (mTOR) and ribosomal protein S6 kinase 1 in the thymus and 
      spleen. These effects were also observed upon prolonged spermine administration 
      (p < 0.05). In summary, dietary spermine supplementation can alleviate 
      inflammatory response, enhance the immune function and regulate the gene 
      expression of signalling molecules related to inflammation.
FAU - Cao, Wei
AU  - Cao W
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Wu, Xianjian
AU  - Wu X
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Jia, Gang
AU  - Jia G
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Zhao, Hua
AU  - Zhao H
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Chen, Xiaoling
AU  - Chen X
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Wu, Caimei
AU  - Wu C
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Tang, Jiayong
AU  - Tang J
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Wang, Jing
AU  - Wang J
AD  - c Maize Research Institute , Sichuan Agricultural University , Chengdu , China.
FAU - Cai, Jingyi
AU  - Cai J
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
FAU - Liu, Guangmang
AU  - Liu G
AD  - a Institute of Animal Nutrition , Sichuan Agricultural University , Chengdu , 
      China.
AD  - b Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of 
      Education , Sichuan Agricultural University , Chengdu , China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Anim Nutr
JT  - Archives of animal nutrition
JID - 101222433
RN  - 2FZ7Y3VOQX (Spermine)
SB  - IM
MH  - Animal Feed
MH  - Animals
MH  - Diet/*veterinary
MH  - *Dietary Supplements
MH  - Gene Expression Regulation/*immunology
MH  - Immunity, Innate/*immunology
MH  - Inflammation/immunology/metabolism/*veterinary
MH  - Signal Transduction/*immunology
MH  - *Spermine
MH  - Spleen/immunology
MH  - Swine
MH  - Swine Diseases
MH  - Thymus Gland/immunology
OTO - NOTNLM
OT  - Immune response
OT  - inflammation
OT  - piglets
OT  - spermine
OT  - spleen
OT  - thymus
EDAT- 2017/04/22 06:00
MHDA- 2017/12/06 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/04/22 06:00 [entrez]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
AID - 10.1080/1745039X.2017.1314610 [doi]
PST - ppublish
SO  - Arch Anim Nutr. 2017 Jun;71(3):175-191. doi: 10.1080/1745039X.2017.1314610.