PMID- 28430338
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20211204
IS  - 1724-6008 (Electronic)
IS  - 0393-6155 (Linking)
VI  - 32
IP  - 3
DP  - 2017 Jul 24
TI  - YAP, TAZ and AREG expression in eighth cranial nerve schwannoma.
PG  - e319-e324
LID - 7CC0E096-ADC8-415A-B375-C7A4E9260460 [pii]
LID - 10.5301/ijbm.5000263 [doi]
AB  - BACKGROUND: Although the diagnosis and treatment of eighth cranial nerve (VIII 
      CN) schwannoma (acoustic neuroma) has improved over the years, no factors capable 
      of predicting tumor growth have been identified as yet. This study is a 
      preliminary investigation of the expression in sporadic VIII CN schwannomas of 
      Yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif 
      (TAZ), and amphiregulin (AREG), a direct target gene of YAP and TAZ. The 
      expression of YAP, TAZ and AREG was correlated with the volumetric dimensions of 
      tumors on contrast-enhanced magnetic resonance imaging (ceMRI). METHODS: YAP, TAZ 
      and AREG expression was assessed immunohistochemically in surgical specimens of 
      36 consecutive sporadic VIII CN schwannomas. 3D reconstructions of the tumors and 
      their corresponding volumes in cm3 were obtained from measurements on ceMRI 
      images using the OsiriX(R) software. RESULTS: We found a significant direct 
      correlation between TAZ expression and VIII CN schwannoma volumes on latest 
      preoperative ceMRI (p<0.0003). Mean TAZ expression was also significantly higher 
      in VIII CN schwannomas with a volume >/=2.1 cm3 than in those with a volume <2.1 
      cm3(p<0.0018). No significant correlations emerged for YAP or AREG expression and 
      VIII CN schwannoma volume. CONCLUSIONS: The immunohistochemical expression of TAZ 
      (but not YAP or AREG) correlated significantly with schwannoma volume measured on 
      ceMRI. Further investigations are needed to identify the biological factors 
      influencing tumor proliferation (ideally secreted proteins like AREG) that might 
      be detected using non-invasive approaches (i.e., blood samples).
FAU - Martini, Alessandro
AU  - Martini A
AD  - Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua 
      - Italy.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua 
      - Italy.
FAU - Zanoletti, Elisabetta
AU  - Zanoletti E
AD  - Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua 
      - Italy.
FAU - Cappellesso, Rocco
AU  - Cappellesso R
AD  - Department of Medicine DIMED, Surgical Pathology and Cytopathology Unit, Padua 
      University, Padua - Italy.
FAU - Stramare, Roberto
AU  - Stramare R
AD  - Department of Medicine DIMED, Radiology Unit, Padua University, Padua - Italy.
FAU - Fasanaro, Elena
AU  - Fasanaro E
AD  - Department of Radiotherapy, Veneto Institute of Oncology, Padua - Italy.
FAU - Faccioli, Chiara
AU  - Faccioli C
AD  - Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua 
      - Italy.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Department of Medicine DIMED, Padua University, Padua - Italy.
FAU - Denaro, Luca
AU  - Denaro L
AD  - Department of Neurosciences DNS, Neurosurgery Unit, Padua University, Padua - 
      Italy.
FAU - D'Avella, Domenico
AU  - D'Avella D
AD  - Department of Neurosciences DNS, Neurosurgery Unit, Padua University, Padua - 
      Italy.
FAU - Mazzoni, Antonio
AU  - Mazzoni A
AD  - Department of Neurosciences DNS, Otolaryngology Section, Padua University, Padua 
      - Italy.
FAU - Fassina, Ambrogio
AU  - Fassina A
AD  - Department of Medicine DIMED, Surgical Pathology and Cytopathology Unit, Padua 
      University, Padua - Italy.
LA  - eng
PT  - Journal Article
DEP - 20170724
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (AREG protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Amphiregulin)
RN  - 0 (Phosphoproteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YAP-Signaling Proteins)
RN  - 0 (YAP1 protein, human)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (TAFAZZIN protein, human)
SB  - IM
MH  - Acyltransferases
MH  - Adaptor Proteins, Signal Transducing/*biosynthesis/genetics
MH  - Amphiregulin/*biosynthesis/genetics
MH  - Cranial Nerve Neoplasms/diagnostic imaging/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neurilemmoma/diagnostic imaging/genetics/*metabolism/pathology
MH  - Phosphoproteins/*biosynthesis/genetics
MH  - Transcription Factors/*biosynthesis/genetics
MH  - Vestibulocochlear Nerve/diagnostic imaging/*pathology
MH  - YAP-Signaling Proteins
EDAT- 2017/04/22 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
AID - 7CC0E096-ADC8-415A-B375-C7A4E9260460 [pii]
AID - 10.5301/ijbm.5000263 [doi]
PST - epublish
SO  - Int J Biol Markers. 2017 Jul 24;32(3):e319-e324. doi: 10.5301/ijbm.5000263.