PMID- 28430372
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180519
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 34
IP  - 8
DP  - 2017 Aug
TI  - Retinal nerve fibre layer thickness is reduced in metabolic syndrome.
PG  - 1061-1066
LID - 10.1111/dme.13369 [doi]
AB  - AIMS: To investigate retinal nerve fibre layer (RNFL) thickness in people with 
      metabolic syndrome (MetS) and healthy controls. METHODS: A cross-sectional study 
      was performed from March 2014 to January 2016. All participants underwent 
      anthropometric and serological biochemical measurements, ophthalmological 
      examination, and spectral-domain optical coherence tomography (SD-OCT). 
      Individuals with elevated intraocular pressure, glaucoma, diabetic retinopathy 
      and other ocular disorders were excluded. T-test, Chi square and general linear 
      models were used to analyse the data. RESULTS: In total, 278 eyes from 139 
      participants were investigated [median (interquartile range) age: 37 
      (32-43) years]. RNFL thickness was lower in the nasal superior (107.8 +/- 19.5mum) 
      and temporal superior (135.7 +/- 18.9mum) sectors in MetS group compared with the 
      control group (114.6 +/- 22.4 mum, P = 0.013 and 140.7 +/- 18.2 mum, P = 0.027, 
      respectively). After multiple adjustments for age, gender and the side of the 
      examined [right (OD)/left (OS)] eye, MetS was independently associated with a 
      lower RFNL thickness in the nasal superior (beta = 0.20, P = 0.009) and temporal 
      superior (beta = 0.14, P = 0.048) sectors. RNFL thickness was significantly reduced 
      in participants with higher numbers of metabolic abnormalities, independent of 
      age, gender and the side of the examined eye (P = 0.043). CONCLUSION: Our 
      findings demonstrate that MetS is independently associated with reduced RNFL 
      thickness, suggesting that neurodegeneration is implicated in pathogenesis of 
      MetS.
CI  - (c) 2017 Diabetes UK.
FAU - Zarei, R
AU  - Zarei R
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Anvari, P
AU  - Anvari P
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Eslami, Y
AU  - Eslami Y
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Fakhraie, G
AU  - Fakhraie G
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Mohammadi, M
AU  - Mohammadi M
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Jamali, A
AU  - Jamali A
AD  - Schepens Eye Research Institute/Mass Eye and Ear, Harvard Medical School, Boston, 
      USA.
FAU - Afarideh, M
AU  - Afarideh M
AD  - Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ghajar, A
AU  - Ghajar A
AD  - Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Heydarzade, S
AU  - Heydarzade S
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Esteghamati, A
AU  - Esteghamati A
AD  - Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Moghimi, S
AU  - Moghimi S
AUID- ORCID: 0000-0002-9375-4711
AD  - Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals, Teaching
MH  - Humans
MH  - Iran
MH  - Linear Models
MH  - Male
MH  - Metabolic Syndrome/complications/*physiopathology
MH  - Nerve Fibers, Unmyelinated/*pathology
MH  - Neurodegenerative Diseases/diagnostic imaging/*etiology/pathology
MH  - Obesity, Abdominal/complications
MH  - Obesity, Morbid/complications
MH  - Optic Nerve/*diagnostic imaging/pathology
MH  - Organ Size
MH  - Retina/*diagnostic imaging/pathology
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence
MH  - Waist Circumference
EDAT- 2017/04/22 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
AID - 10.1111/dme.13369 [doi]
PST - ppublish
SO  - Diabet Med. 2017 Aug;34(8):1061-1066. doi: 10.1111/dme.13369. Epub 2017 May 25.