PMID- 28430613 OWN - NLM STAT- MEDLINE DCOM- 20180305 LR - 20220321 IS - 1949-2553 (Electronic) IS - 1949-2553 (Linking) VI - 8 IP - 18 DP - 2017 May 2 TI - Development of comprehensive nomograms for evaluating overall and cancer-specific survival of laryngeal squamous cell carcinoma patients treated with neck dissection. PG - 29722-29740 LID - 10.18632/oncotarget.15414 [doi] AB - BACKGROUND: Neck dissection for laryngeal squamous cell carcinoma (LSCC) patients could provide complementary prognostic information for AJCC N staging, like lymph node ratio (LNR). The aim of this study was to develop effective nomograms to better predict survival for LSCC patients treated with neck dissection. RESULTS: 2752 patients were identified and randomly divided into training (n = 2477) and validation (n = 275) cohorts. The 3- and 5-year probabilities of cancer-specific mortality (CSM) were 30.1% and 37.2% while 3- and 5-year death resulting from other causes (DROC) rate were 6.2% and 11.3%, respectively. 13 significant prognostic factors including LNR for overall (OS) and 12 (except race) for CSS were enrolled in the nomograms. Concordance index as a commonly used indicator of predictive performance, showed the nomograms had superiority over the no-LNR models and TNM classification (Training-cohort: OS: 0.713 vs 0.703 vs 0.667, CSS: 0.725 vs 0.713 vs 0.688; Validation-cohort: OS: 0.704 vs 0.690 vs 0.658, cancer-specific survival (CSS): 0.709 vs 0.693 vs 0.672). All calibration plots revealed good agreement between nomogram prediction and actual survival. MATERIALS AND METHODS: We identified LSCC patients undergoing neck dissection diagnosed between 1988 and 2008 from Surveillance, Epidemiology, and End Results (SEER) database. Optimal cutoff points were determined by X-tile program. Cumulative incidence function was used to analyze cancer-specific mortality (CSM) and death resulting from other causes (DROC). Significant predictive factors were used to establish nomograms estimating overall (OS) and cancer-specific survival (CSS). The nomograms were bootstrapped validated both internally and externally. CONCLUSIONS: Comprehensive nomograms were constructed to predict OS and CSS for LSCC patients treated with neck dissection more accurately. FAU - Shi, Xiao AU - Shi X AD - Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. AD - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. FAU - Hu, Wei-Ping AU - Hu WP AD - Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. FAU - Ji, Qing-Hai AU - Ji QH AD - Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. AD - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. LA - eng PT - Journal Article PL - United States TA - Oncotarget JT - Oncotarget JID - 101532965 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Carcinoma, Squamous Cell/diagnosis/epidemiology/*mortality/surgery MH - Cause of Death MH - Female MH - Humans MH - Incidence MH - Laryngeal Neoplasms/diagnosis/epidemiology/*mortality/surgery MH - Male MH - Middle Aged MH - Neoplasm Staging MH - Nomograms MH - Reproducibility of Results MH - SEER Program MH - Survival Rate MH - Treatment Outcome MH - Tumor Burden MH - Young Adult PMC - PMC5444698 OTO - NOTNLM OT - cancer-specific survival OT - laryngeal squamous cell carcinoma OT - lymph node ratio OT - nomogram OT - overall survival COIS- CONFLICTS OF INTERESTS None of the authors have any conflicts of interest to declare. EDAT- 2017/04/22 06:00 MHDA- 2018/03/06 06:00 PMCR- 2017/05/02 CRDT- 2017/04/22 06:00 PHST- 2016/11/30 00:00 [received] PHST- 2017/02/01 00:00 [accepted] PHST- 2017/04/22 06:00 [pubmed] PHST- 2018/03/06 06:00 [medline] PHST- 2017/04/22 06:00 [entrez] PHST- 2017/05/02 00:00 [pmc-release] AID - 15414 [pii] AID - 10.18632/oncotarget.15414 [doi] PST - ppublish SO - Oncotarget. 2017 May 2;8(18):29722-29740. doi: 10.18632/oncotarget.15414.