PMID- 28431209
OWN - NLM
STAT- MEDLINE
DCOM- 20170816
LR  - 20220317
IS  - 1520-4812 (Electronic)
IS  - 1043-1802 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Jun 21
TI  - Drug Delivery Systems Based on Hydroxyethyl Starch.
PG  - 1611-1624
LID - 10.1021/acs.bioconjchem.7b00186 [doi]
AB  - The advantageous biological properties of hydroxyethyl starch (HES) triggered 
      research interest toward the design and synthesis of drug delivery systems (DDSs) 
      based on this polysaccharide. Convenient reaction schemes, including one-step 
      reactions, led to the synthesis of HES conjugates with selected anticancer 
      molecules or therapeutic proteins. Nanocapsules and hydrogels based on HES were 
      also prepared and studied as prospective drug delivery systems. Formulations 
      originating from these drug conjugates and also from nanocapsules and hydrogels 
      loaded with drugs were characterized, highlighting the extension of their 
      half-life in plasma, which is a critical property as far as their efficacy is 
      concerned. Results obtained in vitro and in vivo proved promising, justifying the 
      undertaking of additional experiments with such systems, including their 
      multifunctionalization. The promising formulations that are discussed in this 
      Topical Review is expected to further increase interest in applying HES for 
      molecular constructing novel DDSs with enhanced efficacy, which may, in the 
      future, find clinical applications.
FAU - Paleos, Constantinos M
AU  - Paleos CM
AD  - NCSR "Demokritos", Institute of Nanoscience and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki Greece.
AD  - Regulon AE , Apollonos 1, 19400 Koropi, Attiki Greece.
FAU - Sideratou, Zili
AU  - Sideratou Z
AD  - NCSR "Demokritos", Institute of Nanoscience and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki Greece.
FAU - Tsiourvas, Dimitris
AU  - Tsiourvas D
AD  - NCSR "Demokritos", Institute of Nanoscience and Nanotechnology , 15310 Aghia 
      Paraskevi, Attiki Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170510
PL  - United States
TA  - Bioconjug Chem
JT  - Bioconjugate chemistry
JID - 9010319
RN  - 0 (Hydrogels)
RN  - 0 (Hydroxyethyl Starch Derivatives)
RN  - 0 (Nanocapsules)
SB  - IM
EIN - Bioconjug Chem. 2017 Aug 16;28(8):2208-2209. PMID: 28753265
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Hydrogels/chemistry
MH  - Hydroxyethyl Starch Derivatives/chemistry/*therapeutic use
MH  - Nanocapsules/chemistry
EDAT- 2017/04/22 06:00
MHDA- 2017/08/17 06:00
CRDT- 2017/04/22 06:00
PHST- 2017/04/22 06:00 [pubmed]
PHST- 2017/08/17 06:00 [medline]
PHST- 2017/04/22 06:00 [entrez]
AID - 10.1021/acs.bioconjchem.7b00186 [doi]
PST - ppublish
SO  - Bioconjug Chem. 2017 Jun 21;28(6):1611-1624. doi: 
      10.1021/acs.bioconjchem.7b00186. Epub 2017 May 10.