PMID- 28431542
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20221207
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Apr 21
TI  - Effects of periodontal treatment on the medical status of patients with type 2 
      diabetes mellitus: a pilot study.
PG  - 77
LID - 10.1186/s12903-017-0369-2 [doi]
LID - 77
AB  - BACKGROUND: Studies have demonstrated that periodontal disease is associated with 
      the development of systemic complications in patients with type 2 diabetes 
      mellitus (T2DM). The purpose of this pilot study was to investigate which markers 
      among various systemic disease parameters are affected by periodontal treatment 
      in patients with T2DM. METHODS: Twelve patients with T2DM were given oral hygiene 
      instructions and subsequent subgingival scaling and root planing. The periodontal 
      status was recorded, and blood and urine samples were taken to measure various 
      parameters of glucose control and systemic status at baseline and 1 month 
      following the periodontal treatment. Serum concentrations of tumor necrosis 
      factor-alpha and high-sensitivity C-reactive protein were measured by enzyme-linked 
      immunosorbent assay. RESULTS: After the periodontal treatment, the glycated 
      hemoglobin value was significantly improved. The levels of urinary 
      N-acetyl-beta-D-glucosaminidase and albumin, which are markers of renal dysfunction, 
      also decreased significantly after treatment. Among the parameters measured in 
      serum, the gamma-glutamyl transpeptidase level, which is usually interpreted as a 
      marker of liver dysfunction, was significantly reduced. The serum concentrations 
      of tumor necrosis factor-alpha and high-sensitivity C-reactive protein were also 
      significantly reduced by periodontal treatment. CONCLUSION: Within the 
      limitations of this pilot study, periodontal treatment may be effective not only 
      in improving metabolic control, but also in reducing the risk of diabetic kidney 
      and liver disease in patients with T2DM.
FAU - Hayashi, Joichiro
AU  - Hayashi J
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan. hayashi@dent.meikai.ac.jp.
FAU - Hasegawa, Akihiko
AU  - Hasegawa A
AD  - Meikai University School of Dentistry, Saitama-ken, Japan.
FAU - Hayashi, Kohei
AU  - Hayashi K
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Suzuki, Takafumi
AU  - Suzuki T
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Ishii, Makiko
AU  - Ishii M
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Otsuka, Hideharu
AU  - Otsuka H
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Yatabe, Kazuhiro
AU  - Yatabe K
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Goto, Seiichi
AU  - Goto S
AD  - Meikai University School of Dentistry, Saitama-ken, Japan.
FAU - Tatsumi, Junichi
AU  - Tatsumi J
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
FAU - Shin, Kitetsu
AU  - Shin K
AD  - Division of Periodontology, Department of Oral Biology and Tissue Engineering, 
      Meikai University School of Dentistry, 1-1 Keyakidai, Sakado-shi, Saitama-ken, 
      350-0283, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170421
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/urine
MH  - Albuminuria/diagnosis
MH  - Biomarkers/*blood/urine
MH  - C-Reactive Protein/metabolism
MH  - Chronic Periodontitis/*blood/*therapy/urine
MH  - Dental Scaling
MH  - Diabetes Mellitus, Type 2/*blood/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oral Hygiene
MH  - Periodontal Index
MH  - Pilot Projects
MH  - Root Planing
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC5399866
OTO - NOTNLM
OT  - Glycated hemoglobin
OT  - Periodontal treatment
OT  - Type 2 diabetes mellitus
OT  - Urinary N-acetyl-beta-D-glucosaminidase
OT  - gamma-glutamyl transpeptidase
EDAT- 2017/04/23 06:00
MHDA- 2018/07/03 06:00
PMCR- 2017/04/21
CRDT- 2017/04/23 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/04/12 00:00 [accepted]
PHST- 2017/04/23 06:00 [entrez]
PHST- 2017/04/23 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/04/21 00:00 [pmc-release]
AID - 10.1186/s12903-017-0369-2 [pii]
AID - 369 [pii]
AID - 10.1186/s12903-017-0369-2 [doi]
PST - epublish
SO  - BMC Oral Health. 2017 Apr 21;17(1):77. doi: 10.1186/s12903-017-0369-2.