PMID- 28432877
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20190121
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Print)
IS  - 0955-2863 (Linking)
VI  - 45
DP  - 2017 Jul
TI  - Maternal low-protein diet decreases brain-derived neurotrophic factor expression 
      in the brains of the neonatal rat offspring.
PG  - 54-66
LID - S0955-2863(16)30660-X [pii]
LID - 10.1016/j.jnutbio.2017.03.005 [doi]
AB  - Prenatal exposure to a maternal low-protein (LP) diet has been known to cause 
      cognitive impairment, learning and memory deficits. However, the underlying 
      mechanisms have not been identified. Herein, we demonstrate that a maternal LP 
      diet causes, in the brains of the neonatal rat offspring, an attenuation in the 
      basal expression of the brain-derived neurotrophic factor (BDNF), a neurotrophin 
      indispensable for learning and memory. Female rats were fed either a 20% normal 
      protein (NP) diet or an 8% LP 3 weeks before breeding and during the gestation 
      period. Maternal LP diet caused a significant reduction in the Bdnf expression in 
      the brains of the neonatal rats. We further found that the maternal LP diet 
      reduced the activation of the cAMP/protein kinase A/cAMP response element binding 
      protein (CREB) signaling pathway. This reduction was associated with a 
      significant decrease in CREB binding to the Bdnf promoters. We also show that 
      prenatal exposure to the maternal LP diet results in an inactive or repressed 
      exon I and exon IV promoter of the Bdnf gene in the brain, as evidenced by fluxes 
      in signatory hallmarks in the enrichment of acetylated and trimethylated histones 
      in the nucleosomes that envelop the exon I and exon IV promoters, causing the 
      Bdnf gene to be refractory to transactivation. Our study is the first to 
      determine the impact of a maternal LP diet on the basal expression of BDNF in the 
      brains of the neonatal rats exposed prenatally to an LP diet.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Marwarha, Gurdeep
AU  - Marwarha G
AD  - Department of Biomedical Sciences, School of Medicine & Health Sciences, 
      University of North Dakota, Grand Forks, ND 58203, USA.
FAU - Claycombe-Larson, Kate
AU  - Claycombe-Larson K
AD  - U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human 
      Nutrition Research Center, Grand Forks, ND 58203, USA.
FAU - Schommer, Jared
AU  - Schommer J
AD  - Department of Biomedical Sciences, School of Medicine & Health Sciences, 
      University of North Dakota, Grand Forks, ND 58203, USA.
FAU - Ghribi, Othman
AU  - Ghribi O
AD  - Department of Biomedical Sciences, School of Medicine & Health Sciences, 
      University of North Dakota, Grand Forks, ND 58203, USA. Electronic address: 
      othman.ghribi@med.und.edu.
LA  - eng
GR  - R01 AG045264/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170406
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Histones)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Acetylation
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cyclic AMP/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - Diet, Protein-Restricted/*adverse effects
MH  - Female
MH  - Histones/metabolism
MH  - Male
MH  - Pregnancy
MH  - Promoter Regions, Genetic
MH  - Rats, Sprague-Dawley
PMC - PMC5466833
MID - NIHMS866130
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cyclic adenosine monophosphate
OT  - Histone acetylation
OT  - Histone methylation
OT  - Maternal low-protein diet
OT  - cAMP response element binding protein
COIS- Conflict of Interest The authors declare no conflicts of interest.
EDAT- 2017/04/23 06:00
MHDA- 2018/03/27 06:00
PMCR- 2018/07/01
CRDT- 2017/04/23 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/02/08 00:00 [revised]
PHST- 2017/03/16 00:00 [accepted]
PHST- 2017/04/23 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/04/23 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S0955-2863(16)30660-X [pii]
AID - 10.1016/j.jnutbio.2017.03.005 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2017 Jul;45:54-66. doi: 10.1016/j.jnutbio.2017.03.005. Epub 2017 
      Apr 6.