PMID- 2843384
OWN - NLM
STAT- MEDLINE
DCOM- 19881018
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 150
IP  - 3
DP  - 1988 Jun 10
TI  - Analgesic and tolerance-inducing effects of the highly selective delta opioid 
      agonist [D-Pen2,D-Pen5]enkephalin in mice.
PG  - 347-53
AB  - The novel and highly selective, conformationally restricted enkephalin analogue 
      for delta-opioid receptors, [D-Pen2,D-Pen5]enkephalin (DPDPE; Pen = 
      penicillamine), was studied in various in vivo tests for analgesia, tolerance and 
      physical dependence. Intracerebroventricular (i.c.v.) administration of DPDPE 
      caused a dose-dependent, naloxone-reversible antinociception, measured with the 
      heat-irradiant (tail-flick) method. Acute tolerance developed to the 
      antinociceptive effect of DPDPE. DPDPE also caused mild signs of physical 
      dependence (withdrawal hypothermia and body weight loss) after repeated peptide 
      treatment. Severe signs of morphine withdrawal (e.g. withdrawal jumping) on the 
      other hand, could not be reversed by the administration of DPDPE. It is concluded 
      that the activation of central delta-opioid receptors may play a role in 
      controlling pain mechanisms, and that this activation is followed by the rapid 
      development of a tolerance to this action.
FAU - Kovacs, G L
AU  - Kovacs GL
AD  - Institute of Pathophysiology, University Medical School, Szeged, Hungary.
FAU - Nyolczas, N
AU  - Nyolczas N
FAU - Krivan, M
AU  - Krivan M
FAU - Gulya, K
AU  - Gulya K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 76I7G6D29C (Morphine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Drug Tolerance
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalins/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/pharmacology
MH  - Morphine Dependence/psychology
MH  - Pain/physiopathology
MH  - Reaction Time/drug effects
MH  - Receptors, Opioid/*metabolism
MH  - Receptors, Opioid, delta
MH  - Sensory Thresholds/drug effects
MH  - Substance-Related Disorders/psychology
EDAT- 1988/06/10 00:00
MHDA- 1988/06/10 00:01
CRDT- 1988/06/10 00:00
PHST- 1988/06/10 00:00 [pubmed]
PHST- 1988/06/10 00:01 [medline]
PHST- 1988/06/10 00:00 [entrez]
AID - 0014-2999(88)90017-9 [pii]
AID - 10.1016/0014-2999(88)90017-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1988 Jun 10;150(3):347-53. doi: 10.1016/0014-2999(88)90017-9.