PMID- 28434009
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20180618
IS  - 1421-9859 (Electronic)
IS  - 0378-5866 (Linking)
VI  - 39
IP  - 1-4
DP  - 2017
TI  - Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates.
PG  - 49-58
LID - 10.1159/000467392 [doi]
AB  - This review aims to highlight a possible relationship between hypoxic-ischaemic 
      encephalopathy (HIE) and the disruption of the blood-brain barrier (BBB). 
      Inflammatory reactions perpetuate a large proportion of cerebral injury. The 
      extent of injury noted in HIE is not only determined by the biochemical cascades 
      that trigger the apoptosis-necrosis continuum of cell death in the brain 
      parenchyma, but also by the breaching of the BBB by pro-inflammatory factors. We 
      examine the changes that contribute to the breakdown of the BBB that occur during 
      HIE at a macroscopic, cellular, and molecular level. The BBB is a permeability 
      barrier which separates a large majority of brain areas from the systemic 
      circulation. The concept of a physiological BBB is based at the anatomical level 
      on the neurovascular unit (NVU). The NVU consists of various cellular components 
      that jointly regulate the exchanges that occur at the interface between the 
      systemic circulation and the brain parenchyma. There is increased understanding 
      of the contribution of the components of the NVU, e.g., astrocytes and pericytes, 
      to the maintenance of this physiological barrier. We also explore the development 
      of therapeutic options in HIE, such as harnessing the transport systems in the 
      BBB, to enable the delivery of large molecules with molecular Trojan horse 
      technology, and the reinforcement of the physical barrier with cell-based therapy 
      which utilizes endothelial progenitor cells and stem cells.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Lee, Wei Ling Amelia
AU  - Lee WLA
AD  - Barts and the London School of Medicine and Dentistry, Queen Mary University of 
      London, London, UK.
FAU - Michael-Titus, Adina T
AU  - Michael-Titus AT
FAU - Shah, Divyen K
AU  - Shah DK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170422
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
SB  - IM
MH  - Animals
MH  - Asphyxia Neonatorum/*pathology
MH  - Blood-Brain Barrier/*pathology
MH  - Humans
MH  - Hypoxia-Ischemia, Brain/*pathology
MH  - Infant, Newborn
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Endothelial progenitor cells
OT  - Hypoxic-ischaemic encephalopathy
OT  - Molecular Trojan horse technology
OT  - Neurovascular unit
OT  - Vascular endothelial growth factor
EDAT- 2017/04/24 06:00
MHDA- 2018/02/14 06:00
CRDT- 2017/04/24 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/04/24 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2017/04/24 06:00 [entrez]
AID - 000467392 [pii]
AID - 10.1159/000467392 [doi]
PST - ppublish
SO  - Dev Neurosci. 2017;39(1-4):49-58. doi: 10.1159/000467392. Epub 2017 Apr 22.