PMID- 28434145
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 9
IP  - 2
DP  - 2018 Feb
TI  - mTORC1 signaling in hepatic lipid metabolism.
PG  - 145-151
LID - 10.1007/s13238-017-0409-3 [doi]
AB  - The mechanistic target of rapamycin (mTOR) signaling pathway regulates many 
      metabolic and physiological processes in different organs or tissues. 
      Dysregulation of mTOR signaling has been implicated in many human diseases 
      including obesity, diabetes, cancer, fatty liver diseases, and neuronal 
      disorders. Here we review recent progress in understanding how mTORC1 (mTOR 
      complex 1) signaling regulates lipid metabolism in the liver.
FAU - Han, Jinbo
AU  - Han J
AD  - MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, 
      School of Life Sciences, Tsinghua University, Beijing, 100084, China.
FAU - Wang, Yiguo
AU  - Wang Y
AD  - MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, 
      School of Life Sciences, Tsinghua University, Beijing, 100084, China. 
      wangyiguo@biomed.tsinghua.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170422
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Lipid Metabolism
MH  - Lipogenesis
MH  - Liver/*cytology/*metabolism/pathology
MH  - Mechanistic Target of Rapamycin Complex 1/*metabolism
MH  - *Signal Transduction
PMC - PMC5818363
OTO - NOTNLM
OT  - lipogenesis
OT  - lipophagy
OT  - mTOR
OT  - mTORC1
EDAT- 2017/04/24 06:00
MHDA- 2019/01/23 06:00
PMCR- 2017/04/22
CRDT- 2017/04/24 06:00
PHST- 2017/03/02 00:00 [received]
PHST- 2017/04/04 00:00 [accepted]
PHST- 2017/04/24 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2017/04/24 06:00 [entrez]
PHST- 2017/04/22 00:00 [pmc-release]
AID - 10.1007/s13238-017-0409-3 [pii]
AID - 409 [pii]
AID - 10.1007/s13238-017-0409-3 [doi]
PST - ppublish
SO  - Protein Cell. 2018 Feb;9(2):145-151. doi: 10.1007/s13238-017-0409-3. Epub 2017 
      Apr 22.