PMID- 28434771
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20171004
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 35
IP  - 8
DP  - 2017 Aug
TI  - Pharmacological management of cerebral venous sinus thrombosis with full-dose IV 
      heparin infusion and its clinical outcomes.
PG  - 1208.e1-1208.e3
LID - S0735-6757(17)30207-3 [pii]
LID - 10.1016/j.ajem.2017.03.041 [doi]
AB  - OBJECTIVE: To report a case of successful use of unfractionated heparin (UFH) 
      infusion to treat cerebral venous sinus thrombosis (CVST). CASE SUMMARY: A 
      54-year-old female with a history of ovarian cancer addressed through palliative 
      care, presents to the Emergency Department complaining of nausea, vomiting and 
      headache for the last 72h. The patient was on a home regimen of enoxaparin 
      1.5mg/kg subcutaneously daily for recent pulmonary embolism and deep vein 
      thrombosis that developed while on warfarin therapy previously. CT scan showed 
      superior sagittal sinus thrombosis. UFH infusion was initiated and continued for 
      48h until the headache dissipated. DISCUSSION: Stable CVST may be treated with 
      UFH infusion; however, there is limited literature that describes UFH dosing for 
      CVST management. CONCLUSIONS: UFH may be considered as one of the pharmacological 
      agents to manage CVST. The dosing for UFH bolus and infusion is similar to 
      treatment dose for pulmonary embolism/deep vein thrombosis management with goal 
      anti-Xa between 0.3 and 0.7units/mL.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Fernandez, Andrea
AU  - Fernandez A
AD  - Providence St. Peter Hospital, 413 Lily Rd NE Olympia, WA 98506, United States. 
      Electronic address: andreacamille.fernandez@providence.org.
FAU - Nair, Vidya
AU  - Nair V
AD  - Providence St. Peter Hospital, 413 Lily Rd NE Olympia, WA 98506, United States. 
      Electronic address: vidya.nair@providence.org.
FAU - Mckeone, Anna
AU  - Mckeone A
AD  - FACEP, Department of Emergency Medicine, United States.
FAU - Ho, Joseph
AU  - Ho J
AD  - FACEP, Department of Neurosurgery, United States. Electronic address: 
      joseph.ho@providence.org.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170318
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Comorbidity
MH  - Drug Administration Schedule
MH  - Enoxaparin/*therapeutic use
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Infusions, Intravenous
MH  - Middle Aged
MH  - Pulmonary Embolism/*drug therapy
MH  - Sinus Thrombosis, Intracranial/*diagnosis/drug therapy
MH  - Treatment Outcome
MH  - Venous Thrombosis/*prevention & control
MH  - Warfarin/*therapeutic use
OTO - NOTNLM
OT  - CVST
OT  - Cerebral sinus thrombosis
OT  - Full-dose heparin
OT  - Heparin
OT  - Thrombosis
EDAT- 2017/04/25 06:00
MHDA- 2017/10/05 06:00
CRDT- 2017/04/25 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/03/15 00:00 [revised]
PHST- 2017/03/16 00:00 [accepted]
PHST- 2017/04/25 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2017/04/25 06:00 [entrez]
AID - S0735-6757(17)30207-3 [pii]
AID - 10.1016/j.ajem.2017.03.041 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2017 Aug;35(8):1208.e1-1208.e3. doi: 10.1016/j.ajem.2017.03.041. 
      Epub 2017 Mar 18.