PMID- 28435004 OWN - NLM STAT- MEDLINE DCOM- 20180709 LR - 20180709 IS - 1532-8414 (Electronic) IS - 1071-9164 (Linking) VI - 23 IP - 6 DP - 2017 Jun TI - Improvements in Left Ventricular Diastolic Mechanics After Parachute Device Implantation in Patients With Ischemia Heart Failure: A Cardiac Computerized Tomographic Study. PG - 455-463 LID - S1071-9164(17)30104-5 [pii] LID - 10.1016/j.cardfail.2017.04.011 [doi] AB - BACKGROUND: Percutaneous ventricular restoration therapy with the use of a left ventricle (LV)-partitioning Parachute device has emerged as a clinical treatment option for LV apical aneurysm after extensive anterior myocardial infarction (AMI). We assessed changes of diastolic mechanics and functional improvements following LV Parachute device implantation by means of cardiac computerized tomography (CCT). METHODS AND RESULTS: CCT data were obtained from 28 patients before and after LV Parachute device implantation. Diastolic functional indices were determined by means of quantitative CCT assessment: 1) transmitral velocities in early (E) and late (A) diastole and ratio (E/A); 2) early diastolic mitral septal tissue velocity (Ea) and E/Ea; and 3) vortex formation time (VFT). Functional improvements were assessed with the use of New York Heart Association (NYHA) functional classification. Among the study patients, there were no significant differences in all transmitral velocities and E/A, though there was significantly increased Ea, reduced E/Ea, and greater VFT 6 months after LV Parachute device implantation. Finally, the improvement of diastolic functional indices after Parachute treatment correlated with observed clinical functional alterations (Delta E/Ea and Delta NYHA functional class:, r = 0.563; P = .002; Delta VFT and Delta NYHA functional class: r = -0.507; P = .006). CONCLUSIONS: LV Parachute device implantation therapy in heart failure caused by AMI and LV apical aneurysm formation showed improvements in several diastolic functional mechanics according to CCT-based measures. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Yun, Chun-Ho AU - Yun CH AD - Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, Taipei, Taiwan; Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Sun, Jing-Yi AU - Sun JY AD - Department of Biomedical Imaging and Radiologic Sciences, National Yang Ming University, Taipei, Taiwan. FAU - Templin, Barry AU - Templin B AD - Cardiokinetix, Menlo Park, California. FAU - Lin, Shih-Hsuan AU - Lin SH AD - Department of Biomedical Imaging and Radiologic Sciences, National Yang Ming University, Taipei, Taiwan. FAU - Chen, Kuan-Ming AU - Chen KM AD - Department of Biomedical Imaging and Radiologic Sciences, National Yang Ming University, Taipei, Taiwan. FAU - Wu, Tung-Hsin AU - Wu TH AD - Department of Biomedical Imaging and Radiologic Sciences, National Yang Ming University, Taipei, Taiwan. Electronic address: tung@ym.edu.tw. FAU - Hung, Chung-Lieh AU - Hung CL AD - Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, Taipei, Taiwan; Department of Internal Medicine, Division of Cardiology, Mackay Memorial Hospital, Taipei, Taiwan. Electronic address: jotaro3791@gmail.com. FAU - Liu, Chun-Chieh AU - Liu CC AD - Department of Internal Medicine, Division of Cardiology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Hsu, Hsi-Hsien AU - Hsu HH AD - Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, Taipei, Taiwan. FAU - Alaiti, Mohamad Amer AU - Alaiti MA AD - Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, Ohio. FAU - Fares, Anas AU - Fares A AD - Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, Ohio. FAU - DeCicco, Anthony AU - DeCicco A AD - Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, Ohio. FAU - Bezerra, Hiram G AU - Bezerra HG AD - Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, Ohio. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20170420 PL - United States TA - J Card Fail JT - Journal of cardiac failure JID - 9442138 SB - IM MH - Aged MH - Female MH - Heart Failure/*diagnostic imaging/physiopathology/surgery MH - Heart-Assist Devices/*trends MH - Humans MH - Male MH - Middle Aged MH - Myocardial Ischemia/*diagnostic imaging/physiopathology/surgery MH - Retrospective Studies MH - Tomography, X-Ray Computed/*trends MH - Treatment Outcome MH - Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology/surgery MH - Ventricular Function, Left/*physiology OTO - NOTNLM OT - Parachute OT - computer tomography OT - diastolic function OT - heart failure EDAT- 2017/04/25 06:00 MHDA- 2018/07/10 06:00 CRDT- 2017/04/25 06:00 PHST- 2016/11/01 00:00 [received] PHST- 2017/04/07 00:00 [revised] PHST- 2017/04/18 00:00 [accepted] PHST- 2017/04/25 06:00 [pubmed] PHST- 2018/07/10 06:00 [medline] PHST- 2017/04/25 06:00 [entrez] AID - S1071-9164(17)30104-5 [pii] AID - 10.1016/j.cardfail.2017.04.011 [doi] PST - ppublish SO - J Card Fail. 2017 Jun;23(6):455-463. doi: 10.1016/j.cardfail.2017.04.011. Epub 2017 Apr 20.