PMID- 28435241
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20181113
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 12
DP  - 2017
TI  - Magnitude of exercise capacity and quality of life improvement following repeat 
      pulmonary rehabilitation in patients with COPD.
PG  - 1085-1091
LID - 10.2147/COPD.S131778 [doi]
AB  - BACKGROUND: Maintenance and repeated pulmonary rehabilitation programs (PRPs) for 
      patients with COPD have attempted to prolong PRP benefits beyond 12-24 months. 
      However, there is limited evidence as to the magnitude of benefit or the ideal 
      interval between repeating the program under "real-world" conditions in which 
      patients are referred based on clinical necessity. Therefore, we reviewed the 
      effects of repeating PRP in a physician-referred cohort of patients with COPD. 
      METHODS: A total of 141 individuals with COPD completed PRP twice and 35 
      completed PRP three times over a 12-year period. We used linear mixed-effects 
      models to quantify the magnitude and change in 6-minute walk distance (6MWD), St 
      George's Respiratory Questionnaire (SGRQ), and Hospital Anxiety and Depression 
      Scale (HADS) for each PRP. One-way analysis of variance with Tukey's post hoc 
      analysis compared the effects of different time intervals on 6MWD, SGRQ, and HADS 
      between PRPs. RESULTS: Despite 39 mL/year average decrease in forced expiratory 
      volume in 1 second, overall 6MWD improved following each PRP (PRP1=58 m, 
      P<0.0001; PRP2=42 m, P<0.0001; PRP3=32 m, P<0.003). Mean SGRQ decreased after 
      PRP1 (-7.0 units; P<0.001) and PRP2 (-4.9 units; P<0.0001) but not after PRP3 
      (-3.2 units; P=0.10). HADS decreased after PRP1 (-1.9 units; P<0.0001) and PRP2 
      (-1.7 units; P=0.0001) but not after PRP3 (-0.4 units; P=0.63). CONCLUSION: In 
      physician-referred patients who underwent repeat PRP as clinically required, 
      there were clear benefits in functional exercise capacity following each repeat 
      PRP, which was not affected by the time interval between PRPs. Health-related 
      quality of life and mood improved after the first two PRPs, but not after a 
      third.
FAU - Sandoz, Jacqueline S
AU  - Sandoz JS
AD  - Respiratory Ambulatory Care Service, Western Sydney Local Health District, NSW, 
      Australia.
AD  - Canadian Alternatives in Non-invasive Ventilation (CANVent) Program, Ottawa 
      Hospital Rehabilitation Centre, Division of Respiratory Medicine, Ottawa 
      Hospital, Ontario, Canada.
FAU - Roberts, Mary M
AU  - Roberts MM
AD  - Respiratory Ambulatory Care Service, Western Sydney Local Health District, NSW, 
      Australia.
AD  - Department of Respiratory and Sleep Medicine, Westmead Hospital.
AD  - Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical 
      Research.
FAU - Cho, Jin-Gun
AU  - Cho JG
AD  - Respiratory Ambulatory Care Service, Western Sydney Local Health District, NSW, 
      Australia.
AD  - Department of Respiratory and Sleep Medicine, Westmead Hospital.
AD  - Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical 
      Research.
AD  - Sydney Medical School, University of Sydney, Westmead, NSW, Australia.
FAU - Wheatley, John R
AU  - Wheatley JR
AD  - Respiratory Ambulatory Care Service, Western Sydney Local Health District, NSW, 
      Australia.
AD  - Department of Respiratory and Sleep Medicine, Westmead Hospital.
AD  - Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical 
      Research.
AD  - Sydney Medical School, University of Sydney, Westmead, NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170406
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
SB  - IM
MH  - Affect
MH  - Aged
MH  - Analysis of Variance
MH  - Exercise Therapy/*methods
MH  - *Exercise Tolerance
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Linear Models
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - New South Wales
MH  - Pulmonary Disease, Chronic 
      Obstructive/diagnosis/physiopathology/psychology/*rehabilitation
MH  - *Quality of Life
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Walk Test
PMC - PMC5388229
OTO - NOTNLM
OT  - chronic obstructive pulmonary disease
OT  - exercise test
OT  - exercise therapy
OT  - quality of life
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/04/25 06:00
MHDA- 2018/03/06 06:00
PMCR- 2017/04/06
CRDT- 2017/04/25 06:00
PHST- 2017/04/25 06:00 [entrez]
PHST- 2017/04/25 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/04/06 00:00 [pmc-release]
AID - copd-12-1085 [pii]
AID - 10.2147/COPD.S131778 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2017 Apr 6;12:1085-1091. doi: 
      10.2147/COPD.S131778. eCollection 2017.