PMID- 28437012
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20220317
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 46
IP  - 9
DP  - 2017 Oct
TI  - Leptin and NGF in saliva of patients with diabetes mellitus type 2: A pilot 
      study.
PG  - 853-855
LID - 10.1111/jop.12587 [doi]
AB  - AIMS: This study aimed to measure salivary levels of leptin and nerve growth 
      factor (NGF) in patients with type 2 diabetes (T2D) and to compare with healthy 
      subjects. In addition, markers previously evaluated in diabetes, including 
      insulin, hepatocyte growth factor (HGF), and monocyte chemoattractant protein-1 
      (MCP-1), and markers of inflammation interleukin ([IL]-1b, IL-6, IL-8, Tumor 
      necrosis factor alpha [TNF-alpha]), were also measured in saliva to evaluate possible 
      relationship of these markers with the new analytes evaluated in the study. 
      METHODS: Unstimulated whole saliva was collected by passive drooling from a total 
      of 65 individuals (34 controls and 31 with T2D) and used for leptin, NGF, HGF, 
      MCP-1, insulin, IL-1b, IL-6, IL-8, and TNF-alpha determination. RESULTS: Salivary 
      leptin was 2.1 higher in T2D than in healthy controls (P<.001), while no 
      statistically significant differences were detected between the two groups in 
      salivary concentrations of NGF. Salivary IL-6, TNF-alpha, insulin, and MCP-1 were 
      higher in DM in comparison with controls (P<.05 in all cases). Leptin showed 
      positive significant correlations with MCP-1, IL-6, TNF-alpha, and insulin, while NGF 
      positively correlated with HGF, MCP-1, IL-1 beta, IL-6, and TNF-alpha. CONCLUSIONS: This 
      pilot study indicates that salivary leptin is increased in patients with T2D 
      being positively correlated with insulin and pro-inflammatory cytokines and 
      should be further explored as a non-invasive biomarker of T2D. In addition, 
      salivary NGF was positively correlated with pro-inflammatory cytokines and 
      further studies should be performed to evaluate whether it could be useful to 
      detect diabetic neuropathy in T2D patients.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Tvarijonaviciute, Asta
AU  - Tvarijonaviciute A
AUID- ORCID: 0000-0002-5323-5001
AD  - Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus 
      of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, 
      Spain.
FAU - Castillo, Candela
AU  - Castillo C
AD  - Faculty of Medicine, Department of Oral Medicine, University of Murcia, Murcia, 
      Spain.
FAU - Ceron, Jose J
AU  - Ceron JJ
AD  - Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus 
      of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, 
      Spain.
FAU - Martinez-Subiela, Silvia
AU  - Martinez-Subiela S
AD  - Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus 
      of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, 
      Spain.
FAU - Tecles, Fernando
AU  - Tecles F
AD  - Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus 
      of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, 
      Spain.
FAU - Lopez-Jornet, Pia
AU  - Lopez-Jornet P
AD  - Faculty of Medicine, Department of Oral Medicine, University of Murcia, Murcia, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20170525
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Leptin)
RN  - 0 (NGF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Humans
MH  - Leptin/*analysis/*biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*analysis/*biosynthesis
MH  - Pilot Projects
MH  - Saliva/*chemistry
OTO - NOTNLM
OT  - TNF-alpha
OT  - insulin
OT  - interleukin
OT  - leptin
OT  - saliva
EDAT- 2017/04/25 06:00
MHDA- 2018/06/30 06:00
CRDT- 2017/04/25 06:00
PHST- 2017/04/21 00:00 [accepted]
PHST- 2017/04/25 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
PHST- 2017/04/25 06:00 [entrez]
AID - 10.1111/jop.12587 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2017 Oct;46(9):853-855. doi: 10.1111/jop.12587. Epub 2017 May 
      25.