PMID- 28437507
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20181023
IS  - 2333-0384 (Print)
IS  - 2333-0376 (Linking)
VI  - 31
IP  - 2
DP  - 2017 Spring
TI  - Effects of Experimental Pain and Lidocaine on Mechanical Somatosensory Profile 
      and Face Perception.
PG  - 115-123
LID - 10.11607/ofph.1758 [doi]
AB  - AIMS: To assess the effects of experimental muscle pain and topical lidocaine 
      applied to the skin overlying the masseter muscle on the mechanical somatosensory 
      profile and face perception of the masseter muscle in healthy participants. 
      METHODS: A total of 28 healthy participants received a 45-minute application of a 
      lidocaine or placebo patch to the skin overlying the masseter muscle followed by 
      one injection of 0.2 mL sterile solution of monosodium glutamate. Measurements 
      were taken four times during each session of quantitative sensory testing (QST) 
      (T0 = baseline, T1 = 45 minutes after patch application, T2 = immediately after 
      glutamate injection, and T3 = 25 minutes after the glutamate injection), and the 
      following variables were measured: mechanical detection threshold (MDT), 
      mechanical pain threshold (MPT), pressure pain threshold (PPT), pain report (pain 
      on palpation, pain spreading on palpation, and pain intensity), pain drawing, and 
      perceptual distortion. Multi-way within-subjects analysis of variance (ANOVA) was 
      applied to the data. RESULTS: The highest MDTs were present at T2 (F = 49.28, P < 
      .001), the lowest PPTs were present at T2 and T3 (F = 21.78, P < .001), and the 
      largest magnitude and area of perceptual distortion were reported at T2 (F > 
      6.48, P < .001). CONCLUSION: Short-lasting experimental muscle pain was capable 
      of causing loss of tactile sensitivity as well as perceptual distortion of the 
      face, regardless of preconditioning with a topical lidocaine patch. Short-term 
      application of a lidocaine patch did not significantly affect the mechanical 
      somatosensory profile.
FAU - Costa, Yuri Martins
AU  - Costa YM
FAU - Castrillon, Eduardo E
AU  - Castrillon EE
FAU - Bonjardim, Leonardo Rigoldi
AU  - Bonjardim LR
FAU - Rodrigues Conti, Paulo Cesar
AU  - Rodrigues Conti PC
FAU - Baad-Hansen, Lene
AU  - Baad-Hansen L
FAU - Svensson, Peter
AU  - Svensson P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oral Facial Pain Headache
JT  - Journal of oral & facial pain and headache
JID - 101624698
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
MH  - Administration, Topical
MH  - Adult
MH  - Anesthetics, Local/administration & dosage/*pharmacology
MH  - Biomechanical Phenomena
MH  - Cross-Over Studies
MH  - Facial Recognition/*drug effects
MH  - Female
MH  - Humans
MH  - Lidocaine/administration & dosage/*pharmacology
MH  - Male
MH  - Masseter Muscle/*drug effects
MH  - Musculoskeletal Pain/*drug therapy
MH  - *Pain Measurement
MH  - Sensory Thresholds/drug effects
EDAT- 2017/04/25 06:00
MHDA- 2017/10/05 06:00
CRDT- 2017/04/25 06:00
PHST- 2017/04/25 06:00 [entrez]
PHST- 2017/04/25 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
AID - 10.11607/ofph.1758 [doi]
PST - ppublish
SO  - J Oral Facial Pain Headache. 2017 Spring;31(2):115-123. doi: 10.11607/ofph.1758.