PMID- 28438309 OWN - NLM STAT- MEDLINE DCOM- 20170809 LR - 20211204 IS - 1879-1913 (Electronic) IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 119 IP - 12 DP - 2017 Jun 15 TI - Association of Albuminuria With Cardiac Dysfunction in US Hispanics/Latinos. PG - 2073-2080 LID - S0002-9149(17)30363-6 [pii] LID - 10.1016/j.amjcard.2017.03.039 [doi] AB - Higher urine albumin-to-creatinine ratio (UACR) has been associated with cardiac dysfunction in the general population. We assessed the association of UACR with cardiac structure and function in the Echocardiographic Study of Latinos (Echo-SOL), an ancillary study of the Hispanic Community Health Study/Study of Latinos across 4 US sites. Echo-SOL participants underwent standard 2-dimensional echocardiography, including speckle-tracking strain analysis. UACR was categorized as normal and high-normal (based on the midpoint of values below microalbuminuria), microalbuminuria (>/=17 mg/g for men; >/=25 mg/g for women), and macroalbuminuria (>/=250 mg/g; >/=355 mg/g). Simultaneous assessments were made of left ventricular (LV) mass index and hypertrophy and measures of LV systolic and diastolic dysfunction. We assessed the association of UACR with subclinical cardiac measures, adjusting for sociodemographic and cardiometabolic factors. Among 1,815 participants (median age 54, women 65%), 42% had normal UACR, 43% high-normal UACR, 13% microalbuminuria, and 2% macroalbuminuria. Prevalence of LV hypertrophy was 13%, LV systolic dysfunction (ejection fraction <50%) 3%, and diastolic dysfunction 53%. After covariate adjustment, both micro- and macroalbuminuria were significantly associated with a twofold increase in LV hypertrophy. Microalbuminuria but not macroalbuminuria was associated with worse global longitudinal strain. Elevated UACR, even at high-normal levels, was significantly associated with greater diastolic dysfunction. In conclusion, elevated UACR was associated with LV hypertrophy and diastolic dysfunction in the largest known population sample of US Hispanic/Latinos. Screening and detection of even high-normal UACR could be of value to guide cardiovascular disease prevention efforts among Hispanic/Latino Americans. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Hanna, David B AU - Hanna DB AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. FAU - Xu, Shuo AU - Xu S AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. FAU - Melamed, Michal L AU - Melamed ML AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York. FAU - Gonzalez, Franklyn 2nd AU - Gonzalez F 2nd AD - Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. FAU - Allison, Matthew A AU - Allison MA AD - Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, California. FAU - Bilsker, Martin S AU - Bilsker MS AD - Department of Medicine, University of Miami, Miami, Florida. FAU - Hurwitz, Barry E AU - Hurwitz BE AD - Department of Medicine, University of Miami, Miami, Florida; Department of Psychology, University of Miami, Miami, Florida. FAU - Kansal, Mayank M AU - Kansal MM AD - Department of Medicine, University of Illinois at Chicago, Chicago, Illinois. FAU - Schneiderman, Neil AU - Schneiderman N AD - Department of Medicine, University of Miami, Miami, Florida; Department of Psychology, University of Miami, Miami, Florida. FAU - Shah, Sanjiv J AU - Shah SJ AD - Department of Medicine, Northwestern University, Chicago, Illinois. FAU - Kaplan, Robert C AU - Kaplan RC AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. FAU - Rodriguez, Carlos J AU - Rodriguez CJ AD - Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Epidemiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina. Electronic address: crodrigu@wakehealth.edu. FAU - Kizer, Jorge R AU - Kizer JR AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York. LA - eng GR - R01 HL104199/HL/NHLBI NIH HHS/United States GR - N01HC65236/HL/NHLBI NIH HHS/United States GR - N01HC65235/HL/NHLBI NIH HHS/United States GR - N01HC65234/HL/NHLBI NIH HHS/United States GR - N01HC65233/HL/NHLBI NIH HHS/United States GR - N01HC65237/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Multicenter Study DEP - 20170329 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Biomarkers) RN - AYI8EX34EU (Creatinine) SB - IM MH - Albuminuria/*ethnology/etiology/metabolism MH - Biomarkers/urine MH - Creatinine/urine MH - Diastole MH - Disease Progression MH - Echocardiography MH - Female MH - Heart Ventricles/diagnostic imaging/*physiopathology MH - *Hispanic or Latino MH - Humans MH - Male MH - Middle Aged MH - Prevalence MH - Retrospective Studies MH - Systole MH - United States/epidemiology MH - Ventricular Dysfunction, Left/complications/ethnology/*physiopathology MH - Ventricular Remodeling/*physiology PMC - PMC5609841 MID - NIHMS870498 EDAT- 2017/04/26 06:00 MHDA- 2017/08/10 06:00 PMCR- 2018/06/15 CRDT- 2017/04/26 06:00 PHST- 2016/12/16 00:00 [received] PHST- 2017/03/09 00:00 [revised] PHST- 2017/03/09 00:00 [accepted] PHST- 2017/04/26 06:00 [pubmed] PHST- 2017/08/10 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] PHST- 2018/06/15 00:00 [pmc-release] AID - S0002-9149(17)30363-6 [pii] AID - 10.1016/j.amjcard.2017.03.039 [doi] PST - ppublish SO - Am J Cardiol. 2017 Jun 15;119(12):2073-2080. doi: 10.1016/j.amjcard.2017.03.039. Epub 2017 Mar 29.