PMID- 28438788 OWN - NLM STAT- MEDLINE DCOM- 20170803 LR - 20200225 IS - 1470-7926 (Electronic) IS - 1351-0711 (Print) IS - 1351-0711 (Linking) VI - 74 IP - 7 DP - 2017 Jul TI - Associations between persistent organic pollutants, type 2 diabetes, diabetic nephropathy and mortality. PG - 521-527 LID - 10.1136/oemed-2016-103948 [doi] AB - OBJECTIVE: Relationships were examined between persistent organic pollutants (POPs) and incident type 2 diabetes, end-stage renal disease (ESRD) and mortality. METHODS: In a nested case-control study, 300 persons without diabetes had baseline examinations between 1969 and 1974; 149 developed diabetes (cases) and 151 remained non-diabetic (controls) during 8.0 and 23.1 years of follow-up, respectively. POPs were measured at baseline. ORs for diabetes were computed by logistic regression analysis. The cases were followed from diabetes onset to ESRD, death or 2013. HRs for ESRD and mortality were computed by cause-specific hazard models. Patterns of association were explored using principal components analysis. RESULTS: PCB151 increased the odds for incident diabetes, whereas hexachlorobenzene (HCB) was protective after adjusting for age, sex, body mass index, sample storage characteristics, glucose and lipid levels. Associations between incident diabetes and polychlorinatedbiphenyl (PCB) or persistent pesticide (PST) components were mostly positive but non-significant. Among the cases, 29 developed ESRD and 48 died without ESRD. PCB28, PCB49 and PCB44 increased the risk of ESRD after adjusting for baseline demographic and clinical characteristics. Several PCBs and PSTs increased the risk of death without ESRD. The principal components analysis identified PCBs with low-chlorine load positively associated with ESRD and death without ESRD, and several PSTs associated with death without ESRD. CONCLUSIONS: Most POPs were positively but not significantly associated with incident diabetes. PCB151 was significantly predictive and HCB was significantly protective for diabetes. Among participants with diabetes, low-chlorine PCBs increase the risk of ESRD and death without ESRD, whereas several PSTs predict death without ESRD. CI - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. FAU - Grice, Brian A AU - Grice BA AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. FAU - Nelson, Robert G AU - Nelson RG AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. FAU - Williams, Desmond E AU - Williams DE AD - Division for Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Knowler, William C AU - Knowler WC AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. FAU - Mason, Clinton AU - Mason C AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. FAU - Hanson, Robert L AU - Hanson RL AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. FAU - Bullard, Kai McKeever AU - Bullard KM AD - Division for Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Pavkov, Meda E AU - Pavkov ME AD - Division for Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. LA - eng GR - ZIA DK069062-24/Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20170424 PL - England TA - Occup Environ Med JT - Occupational and environmental medicine JID - 9422759 RN - 0 (Environmental Pollutants) RN - 0 (Fungicides, Industrial) RN - 0 (Organic Chemicals) RN - 0 (Pesticides) RN - 4Z87H0LKUY (Hexachlorobenzene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adolescent MH - Adult MH - Arizona/epidemiology MH - Case-Control Studies MH - Cause of Death MH - Diabetes Mellitus, Type 2/blood/*chemically induced/*epidemiology MH - Diabetic Nephropathies/*chemically induced/*mortality MH - Environmental Exposure/*adverse effects MH - Environmental Pollutants/adverse effects MH - Female MH - Fungicides, Industrial/adverse effects MH - Hexachlorobenzene/adverse effects MH - Humans MH - Indians, North American MH - Kidney Failure, Chronic/*chemically induced/*mortality MH - Logistic Models MH - Male MH - Organic Chemicals/adverse effects MH - Pesticides/*adverse effects MH - Polychlorinated Biphenyls/adverse effects MH - Young Adult PMC - PMC6380355 MID - NIHMS1011858 OTO - NOTNLM OT - Diabetes mellitus OT - PCBs OT - Pesticides OT - Renal COIS- Competing interests: None declared. EDAT- 2017/04/26 06:00 MHDA- 2017/08/05 06:00 PMCR- 2019/02/19 CRDT- 2017/04/26 06:00 PHST- 2016/07/07 00:00 [received] PHST- 2017/02/08 00:00 [revised] PHST- 2017/03/21 00:00 [accepted] PHST- 2017/04/26 06:00 [pubmed] PHST- 2017/08/05 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] PHST- 2019/02/19 00:00 [pmc-release] AID - oemed-2016-103948 [pii] AID - 10.1136/oemed-2016-103948 [doi] PST - ppublish SO - Occup Environ Med. 2017 Jul;74(7):521-527. doi: 10.1136/oemed-2016-103948. Epub 2017 Apr 24.