PMID- 28438823
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20221207
IS  - 1535-2900 (Electronic)
IS  - 1079-2082 (Linking)
VI  - 74
IP  - 9
DP  - 2017 May 1
TI  - Association of human leukocyte antigen variants and allopurinol-induced 
      Stevens-Johnson syndrome and toxic epidermal necrolysis: A meta-analysis.
PG  - e183-e192
LID - 10.2146/ajhp160243 [doi]
AB  - PURPOSE: The association between human leukocyte antigen (HLA) variants and 
      allopurinol-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis 
      (TEN) was evaluated through a pooled analysis of published studies. METHODS: A 
      comprehensive search was performed in multiple databases, including PubMed, 
      MEDLINE, ISI Web of Knowledge, EMBASE, Cochrane Register of Controlled Trials, 
      and Science Direct. Studies investigating the association between HLA alleles 
      with allopurinol-induced SJS or TEN were retrieved, and the data were 
      independently extracted. The overall odds ratios (ORs) with corresponding 95% 
      confidence intervals were calculated to determine the association between the 
      presence of HLA variant in at least one allele and allopurinol-induced SJS or 
      TEN. To test the robustness of the meta-analysis results, a sensitivity analysis 
      was performed by removing each study one at a time and calculating the pooled ORs 
      of the remaining studies. The fixed-effects and random-effects models were used 
      to pool the collected data. RESULTS: A total of 4 studies with 81 
      allopurinol-induced SJS or TEN cases and matched controls (allopurinol-tolerant 
      patients) or population controls (general population) were identified. SJS and 
      TEN were found to be significantly associated with HLA-A*33:03 and HLA-C*03:02 
      alleles in both groups of studies with matched controls and population controls. 
      All of the pooled ORs were not significantly affected by the remaining studies 
      and different modeling methods, indicating robust results. CONCLUSION: A strong 
      association was found between HLA-A*33:03 and HLA-C*03:02 alleles and 
      allopurinol-induced SJS or TEN, especially in an Asian population.
CI  - Copyright (c) 2017 by the American Society of Health-System Pharmacists, Inc. All 
      rights reserved.
FAU - Li, Xingang
AU  - Li X
AD  - Department of Pharmacy, Beijing Tiantan Hospital, Beijing, People's Republic of 
      China.
FAU - Zhao, Zhigang
AU  - Zhao Z
AD  - Department of Pharmacy, Beijing Tiantan Hospital, Beijing, People's Republic of 
      China.
FAU - Sun, Shu-Sen
AU  - Sun SS
AD  - College of Pharmacy, Western New England University, Springfield, MA. 
      ssun@wne.edu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Am J Health Syst Pharm
JT  - American journal of health-system pharmacy : AJHP : official journal of the 
      American Society of Health-System Pharmacists
JID - 9503023
RN  - 0 (Gout Suppressants)
RN  - 0 (HLA Antigens)
RN  - 63CZ7GJN5I (Allopurinol)
SB  - IM
MH  - Allopurinol/*adverse effects
MH  - Asian People/genetics
MH  - Genetic Predisposition to Disease
MH  - Gout/*drug therapy/etiology
MH  - Gout Suppressants
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Hyperuricemia/complications/*drug therapy
MH  - Stevens-Johnson Syndrome/*etiology
OTO - NOTNLM
OT  - HLA-A*33:03
OT  - HLA-C*03:02
OT  - Stevens-Johnson syndrome
OT  - allopurinol
OT  - meta-analysis
OT  - toxic epidermal necrolysis
EDAT- 2017/04/26 06:00
MHDA- 2019/06/07 06:00
CRDT- 2017/04/26 06:00
PHST- 2017/04/26 06:00 [entrez]
PHST- 2017/04/26 06:00 [pubmed]
PHST- 2019/06/07 06:00 [medline]
AID - 74/9/e183 [pii]
AID - 10.2146/ajhp160243 [doi]
PST - ppublish
SO  - Am J Health Syst Pharm. 2017 May 1;74(9):e183-e192. doi: 10.2146/ajhp160243.