PMID- 28439651 OWN - NLM STAT- MEDLINE DCOM- 20180326 LR - 20200330 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) VI - 27 IP - 9 DP - 2017 Sep TI - Contrast-enhanced T1 mapping-based extracellular volume fraction independently predicts clinical outcome in patients with non-ischemic dilated cardiomyopathy: a prospective cohort study. PG - 3924-3933 LID - 10.1007/s00330-017-4817-9 [doi] AB - OBJECTIVES: We aimed to evaluate the prognostic role of cardiac magnetic resonance imaging (CMR)-based extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) and compare it with late gadolinium enhancement (LGE) parameters. METHODS: This was a single-center, prospective, cohort study of 117 NIDCM patients (71 men, 51.9 +/- 16.7 years) who underwent clinical 3.0-T CMR. Myocardial ECV and LGE were quantified on the left ventricular myocardium. The presence of midwall LGE was also detected. Nineteen healthy subjects served as controls. The primary end points were cardiovascular (CV) events defined by CV death, rehospitalization due to heart failure, and heart transplantation. RESULTS: During the follow-up period (median duration, 11.2 months; 25(th)-75(th) percentile, 7.8-21.9 months), the primary end points occurred in 19 patients (16.2%). The ECV (per 3% and 1% increase) was associated with a hazard ratio of 1.80 and 1.22 (95% confidence interval [CI], 1.48-2.20 and 1.14-1.30, respectively; p < 0.001) for the CV events. Multivariable analysis also indicated that ECV was an independent prognostic factor and had a higher prognostic value (Harrell's c statistic, 0.88) than LGE quantification values (0.77) or midwall LGE (0.80). CONCLUSION: CMR-based ECV independently predicts the clinical outcome in NIDCM patients. KEY POINTS: * T1-mapping-based ECV is a useful parameter of risk stratification in NIDCM * ECV has a higher prognostic value than LGE * Contrast-enhanced T1-mapping CMR is a feasible and safe method. FAU - Youn, Jong-Chan AU - Youn JC AD - Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea. AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Hong, Yoo Jin AU - Hong YJ AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. uzzin@yuhs.ac. FAU - Lee, Hye-Jeong AU - Lee HJ AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Han, Kyunghwa AU - Han K AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Shim, Chi Young AU - Shim CY AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Hong, Geu-Ru AU - Hong GR AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Suh, Young Joo AU - Suh YJ AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Hur, Jin AU - Hur J AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Kim, Young Jin AU - Kim YJ AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Choi, Byoung Wook AU - Choi BW AD - Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. FAU - Kang, Seok-Min AU - Kang SM AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20170424 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Cardiomyopathy, Dilated/mortality/*pathology MH - Contrast Media MH - Female MH - Gadolinium MH - Heart/physiopathology MH - Heart Failure/etiology/mortality/pathology MH - Humans MH - Magnetic Resonance Angiography/methods MH - Male MH - Middle Aged MH - Myocardium/pathology MH - Patient Readmission/statistics & numerical data MH - Prognosis MH - Proportional Hazards Models MH - Prospective Studies MH - Ventricular Dysfunction, Left/mortality/pathology OTO - NOTNLM OT - Extracellular space OT - Magnetic resonance imaging OT - Myocardium OT - Prognosis OT - T1 mapping EDAT- 2017/04/26 06:00 MHDA- 2018/03/27 06:00 CRDT- 2017/04/26 06:00 PHST- 2016/08/19 00:00 [received] PHST- 2017/03/17 00:00 [accepted] PHST- 2017/03/03 00:00 [revised] PHST- 2017/04/26 06:00 [pubmed] PHST- 2018/03/27 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] AID - 10.1007/s00330-017-4817-9 [pii] AID - 10.1007/s00330-017-4817-9 [doi] PST - ppublish SO - Eur Radiol. 2017 Sep;27(9):3924-3933. doi: 10.1007/s00330-017-4817-9. Epub 2017 Apr 24.