PMID- 28439652 OWN - NLM STAT- MEDLINE DCOM- 20180716 LR - 20220321 IS - 1432-1084 (Electronic) IS - 0938-7994 (Linking) VI - 27 IP - 11 DP - 2017 Nov TI - Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in hypertension and associated with left ventricular remodeling. PG - 4620-4630 LID - 10.1007/s00330-017-4841-9 [doi] AB - OBJECTIVES: To determine whether extracellular volume fraction (ECV) quantification by cardiac magnetic resonance (CMR) can demonstrate left ventricle (LV) abnormalities and relationship between ECV and LV remodeling in hypertension (HTN) patients METHODS: ECV quantification was prospectively performed in 134 consecutive HTN patients and 97 healthy subjects. Individual and regional ECV were compared to the regions on late gadolinium enhancement (LGE) images. Statistical analysis of the relationship between LV global functional parameters and ECV was carried out using Pearson's correlation, Student's t test and multiple regressions. RESULTS: In the HTN group, 70.1% (94/134) were LGE negative and 29.9% (40/134) LGE positive. The mean ECV after adjusting for age, sex, BMI, diabetes, smoking and dyslipidaemia in healthy controls and LGE-negative patients were 26.9 +/- 2.67% and 28.5 +/- 2.9% (p < 0.001), respectively. The differences in ECV reached statistical significance among the regions of LGE, LGE-Peri, LGE remote and the normal area between the control and LGE-positive subgroup (all p < 0.05). Global ECV significantly correlated with LVEF (r = -0.466, p < 0 .001) and LV hypertrophy (r = 0.667, p < 0.001). CONCLUSIONS: ECV can identify LV abnormalities at an early stage in HTN patients without LGE. These abnormalities may reflect an increase in diffuse myocardial fibrosis and are associated with LV remodeling. KEY POINTS: * Diffuse myocardial fibrosis may develop in hypertensive cardiomyopathy before conventional MRI detectable LGE. * ECV can identify myocardial fibrosis at an early stage in hypertensive patients. * Elevated ECV is associated with decreased LV global function and LV remodeling in hypertension. FAU - Wang, Shuli AU - Wang S AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Hu, Hongjie AU - Hu H AD - Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China. FAU - Lu, Minjie AU - Lu M AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. coolkan@163.com. AD - Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA. coolkan@163.com. FAU - Sirajuddin, Arlene AU - Sirajuddin A AD - Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA. FAU - Li, Jinghui AU - Li J AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - An, Jing AU - An J AD - Siemens Shenzhen Magnetic Resonance Ltd., Siemens MRI Center, Shenzhen, Guangdong, People's Republic of China. FAU - Chen, Xiuyu AU - Chen X AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Yin, Gang AU - Yin G AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Lan, Tian AU - Lan T AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Dai, Linlin AU - Dai L AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Zhang, Yan AU - Zhang Y AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Yin, Xiaorong AU - Yin X AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. FAU - Song, Lei AU - Song L AD - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Dang, Aimin AU - Dang A AD - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Kellman, Peter AU - Kellman P AD - Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), US Department of Health and Human Services, Bethesda, MD, USA. FAU - Arai, Andrew E AU - Arai AE AD - Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA. FAU - Zhao, Shihua AU - Zhao S AD - Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China. LA - eng PT - Journal Article DEP - 20170424 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Female MH - Gadolinium DTPA/*pharmacology MH - Heart Ventricles/*pathology MH - Humans MH - Hypertension/*complications/diagnosis/physiopathology MH - Hypertrophy, Left Ventricular/etiology/*pathology/physiopathology MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Prospective Studies MH - Ventricular Function, Left/*physiology MH - *Ventricular Remodeling OTO - NOTNLM OT - CMR OT - Extracellular volume fraction OT - Fibrosis OT - Hypertension OT - Remodeling EDAT- 2017/04/26 06:00 MHDA- 2018/07/17 06:00 CRDT- 2017/04/26 06:00 PHST- 2016/05/05 00:00 [received] PHST- 2017/04/03 00:00 [accepted] PHST- 2017/03/20 00:00 [revised] PHST- 2017/04/26 06:00 [pubmed] PHST- 2018/07/17 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] AID - 10.1007/s00330-017-4841-9 [pii] AID - 10.1007/s00330-017-4841-9 [doi] PST - ppublish SO - Eur Radiol. 2017 Nov;27(11):4620-4630. doi: 10.1007/s00330-017-4841-9. Epub 2017 Apr 24.