PMID- 28439775 OWN - NLM STAT- MEDLINE DCOM- 20180308 LR - 20181113 IS - 1865-3774 (Electronic) IS - 0925-5710 (Linking) VI - 106 IP - 3 DP - 2017 Sep TI - The prognostic significance of 13q deletions of different sizes in patients with B-cell chronic lymphoproliferative disorders: a retrospective study. PG - 418-425 LID - 10.1007/s12185-017-2240-2 [doi] AB - Patients with chronic lymphocytic leukemia (CLL) with 13q deletion as the sole cytogenetic abnormality usually have a favorable outcome, but the frequency of the 13q14 deletion and its impact on the outcome of other B-cell chronic lymphoproliferative disorders (BCLPDs) remain unclear. To further characterize this aberration, we investigated the prognostic significance of 13q deletion in 541 patients with BCLPDs. We performed fluorescence in situ hybridization (FISH) studies with 13q locus-specific LSI-D13S25 and LSI-RB1 probes. 52.1% of the patients with CLL harbored 13q deletion, which was significantly higher than that of other BCLPDs (p < 0.001). The size of 13q deletion was heterogeneous in both CLL and other BCLPDs. However, the distribution of cases with different deletion sizes showed no significant difference between the two groups. Whereas 13q deletion was a favorable prognostic factor in CLL, a large deletion of 13q was associated with poor prognosis in terms of time to first therapy (p = 0.020), progression-free survival (p = 0.05) and overall survival (p = 0.002) in BCLPD cases other than CLL. In conclusion, the deletion of 13q varied in size both in CLL and in other BCLPDs and adversely influenced the prognosis of patients with other BCLPDs. FAU - Yi, Shuhua AU - Yi S AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Li, Heng AU - Li H AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Li, Zengjun AU - Li Z AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. zengjunli@163.com. FAU - Xiong, Wenjie AU - Xiong W AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Liu, Huimin AU - Liu H AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Liu, Wei AU - Liu W AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Lv, Rui AU - Lv R AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Yu, Zhen AU - Yu Z AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Zou, Dehui AU - Zou D AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Xu, Yan AU - Xu Y AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - An, Gang AU - An G AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. FAU - Qiu, Lugui AU - Qiu L AD - State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288, Nanjing Road, Heping District, Tianjin, 300020, China. qiulg@ihcams.ac.cn. LA - eng GR - 2014BAI09B12/the National Science and Technology Supporting Program/ GR - 81370632/the National Natural Science Foundation of China/ GR - 81400092/the National Natural Science Foundation of China/ GR - 15JCYBJC27900/the Fundamental Application and Advanced Technology Research Program of Tianjin/ GR - 15JCYBJC25100/the Fundamental Application and Advanced Technology Research Program of Tianjin/ PT - Journal Article DEP - 20170424 PL - Japan TA - Int J Hematol JT - International journal of hematology JID - 9111627 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *B-Lymphocytes MH - *Chromosome Deletion MH - Chromosomes, Human, Pair 13/*genetics MH - Chronic Disease MH - Disease-Free Survival MH - Female MH - Humans MH - In Situ Hybridization, Fluorescence MH - Lymphoproliferative Disorders/*genetics/mortality MH - Male MH - Middle Aged MH - Prognosis MH - Retrospective Studies MH - Young Adult OTO - NOTNLM OT - 13q14 deletion OT - BCLPDs OT - Interphase fish OT - Prognosis EDAT- 2017/04/26 06:00 MHDA- 2018/03/09 06:00 CRDT- 2017/04/26 06:00 PHST- 2017/01/19 00:00 [received] PHST- 2017/04/12 00:00 [accepted] PHST- 2017/04/09 00:00 [revised] PHST- 2017/04/26 06:00 [pubmed] PHST- 2018/03/09 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] AID - 10.1007/s12185-017-2240-2 [pii] AID - 10.1007/s12185-017-2240-2 [doi] PST - ppublish SO - Int J Hematol. 2017 Sep;106(3):418-425. doi: 10.1007/s12185-017-2240-2. Epub 2017 Apr 24.