PMID- 28440036 OWN - NLM STAT- MEDLINE DCOM- 20180509 LR - 20220129 IS - 1468-1293 (Electronic) IS - 1464-2662 (Print) IS - 1464-2662 (Linking) VI - 18 IP - 9 DP - 2017 Oct TI - A tale of two countries: all-cause mortality among people living with HIV and receiving combination antiretroviral therapy in the UK and Canada. PG - 655-666 LID - 10.1111/hiv.12505 [doi] AB - OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged >/= 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk. RESULTS: A total of 19 960 participants were included in the analysis (CANOC, 4137; UK CHIC, 15 823). CANOC participants were more likely to be older [median age 39 years (interquartile range (IQR): 33, 46 years) vs. 36 years (IQR: 31, 43 years) for UK CHIC participants], to be male (86 vs. 73%, respectively), and to report men who have sex with men (MSM) sexual transmission risk (72 vs. 56%, respectively) (all P < 0.001). Overall, 762 deaths occurred during 98 798 person-years (PY) of follow-up, giving a crude mortality rate of 7.7 per 1000 PY [95% confidence interval (CI): 7.1, 8.3 per 1000 PY]. The crude mortality rates were 8.6 (95% CI: 7.4, 10.0) and 7.5 (95% CI: 6.9, 8.1) per 1000 PY among CANOC and UK CHIC study participants, respectively. No statistically significant difference in mortality risk was observed between the cohort collaborations in Cox regression accounting for loss to follow-up as a competing risk (adjusted hazard ratio 0.86; 95% CI: 0.72-1.03). CONCLUSIONS: Despite differences in national HIV care provision and treatment guidelines, mortality risk did not differ between CANOC and UK CHIC study participants who acquired HIV through sexual transmission. CI - (c) 2017 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. FAU - Patterson, S AU - Patterson S AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. AD - Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada. FAU - Jose, S AU - Jose S AD - Research Department of Infection and Population Health, University College London, London, UK. FAU - Samji, H AU - Samji H AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. AD - British Columbia Centre for Disease Control, Vancouver, BC, Canada. FAU - Cescon, A AU - Cescon A AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. AD - Northern Ontario School of Medicine, Sudbury, ON, Canada. FAU - Ding, E AU - Ding E AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. FAU - Zhu, J AU - Zhu J AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. FAU - Anderson, J AU - Anderson J AD - Homerton University Hospital NHS Trust, London, UK. FAU - Burchell, A N AU - Burchell AN AD - Department of Family and Community Medicine, St Michael's Hospital, Toronto, ON, Canada. AD - Li Ka Shing Knowledge Institute, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Cooper, C AU - Cooper C AD - The Ottawa Hospital Division of Infectious Diseases, University of Ottawa, Ottawa, ON, Canada. FAU - Hill, T AU - Hill T AD - Research Department of Infection and Population Health, University College London, London, UK. FAU - Hull, M AU - Hull M AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. FAU - Klein, M B AU - Klein MB AD - Faculty of Medicine, McGill University, Montreal, QC, Canada. AD - The Montreal Chest Institute, McGill University Health Centre, Montreal, QC, Canada. FAU - Loutfy, M AU - Loutfy M AD - Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Maple Leaf Medical Clinic, Toronto, ON, Canada. AD - Women's College Research Institute, Toronto, ON, Canada. FAU - Martin, F AU - Martin F AD - York Teaching Hospital NHS Foundation Trust, York, UK. FAU - Machouf, N AU - Machouf N AD - Clinique Medicale l'Actuel, Montreal, QC, Canada. FAU - Montaner, Jsg AU - Montaner J AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. AD - Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Nelson, M AU - Nelson M AD - Chelsea and Westminster Hospital NHS Trust, London, UK. FAU - Raboud, J AU - Raboud J AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Toronto General Research Institute, University Health Network, Toronto, ON, Canada. FAU - Rourke, S B AU - Rourke SB AD - Ontario HIV Treatment Network, Toronto, ON, Canada. FAU - Tsoukas, C AU - Tsoukas C AD - Faculty of Medicine, McGill University, Montreal, QC, Canada. FAU - Hogg, R S AU - Hogg RS AD - British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. AD - Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada. FAU - Sabin, C AU - Sabin C AD - Research Department of Infection and Population Health, University College London, London, UK. CN - Canadian Observational Cohort (CANOC) - UK Collaborative HIV Cohort (UK CHIC) Collaboration LA - eng GR - G0600337/MRC_/Medical Research Council/United Kingdom GR - G0900274/MRC_/Medical Research Council/United Kingdom GR - MC_UU_12023/15/MRC_/Medical Research Council/United Kingdom GR - CIHR/Canada PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20170424 PL - England TA - HIV Med JT - HIV medicine JID - 100897392 RN - 0 (Anti-HIV Agents) SB - IM MH - Adult MH - Anti-HIV Agents/*therapeutic use MH - Canada/epidemiology MH - Cohort Studies MH - Female MH - HIV Infections/*drug therapy/*mortality MH - Humans MH - Male MH - Middle Aged MH - Observational Studies as Topic MH - Risk Factors MH - Sexually Transmitted Diseases, Viral/drug therapy/mortality MH - United Kingdom/epidemiology PMC - PMC5600099 OTO - NOTNLM OT - AIDS OT - HIV OT - UK OT - Canada OT - antiretroviral therapy OT - mortality FIR - Kelly, Deborah IR - Kelly D FIR - Sanche, Stephen IR - Sanche S FIR - Wong, Alexander IR - Wong A FIR - Antoniou, Tony IR - Antoniou T FIR - Bayoumi, Ahmed IR - Bayoumi A FIR - Nosyk, Bohdan IR - Nosyk B FIR - Cotterchio, Michelle IR - Cotterchio M FIR - Goldsmith, Charlie IR - Goldsmith C FIR - Guillemi, Silvia IR - Guillemi S FIR - Richard Harrigan, P IR - Richard Harrigan P FIR - Harris, Marianne IR - Harris M FIR - Hosein, Sean IR - Hosein S FIR - Johnston, Sharon IR - Johnston S FIR - Liddy, Clare IR - Liddy C FIR - Lima, Viviane IR - Lima V FIR - Moore, David IR - Moore D FIR - Palmer, Alexis IR - Palmer A FIR - Phillips, Peter IR - Phillips P FIR - Rachlis, Anita IR - Rachlis A FIR - Smieja, Marek IR - Smieja M FIR - Trottier, Benoit IR - Trottier B FIR - Wainberg, Mark IR - Wainberg M FIR - Walmsley, Sharon IR - Walmsley S FIR - Archibald, Chris IR - Archibald C FIR - Clement, Ken IR - Clement K FIR - Doolittle-Romas, Monique IR - Doolittle-Romas M FIR - Edmiston, Laurie IR - Edmiston L FIR - Huskins, Brian IR - Huskins B FIR - Lawless, Jerry IR - Lawless J FIR - Lee, Douglas IR - Lee D FIR - Masching, Renee IR - Masching R FIR - Tattle, Stephen IR - Tattle S FIR - Zahirieh, Alireza IR - Zahirieh A FIR - Allen, Claire IR - Allen C FIR - Calvez, Stryker IR - Calvez S FIR - Colley, Guillaume IR - Colley G FIR - Chia, Jason IR - Chia J FIR - Corsi, Daniel IR - Corsi D FIR - Gilbert, Louise IR - Gilbert L FIR - Gataric, Nada IR - Gataric N FIR - Leslie, Alia IR - Leslie A FIR - Light, Lucia IR - Light L FIR - Mackie, David IR - Mackie D FIR - Pexos, Costa IR - Pexos C FIR - Shurgold, Susan IR - Shurgold S FIR - Szadkowski, Leah IR - Szadkowski L FIR - Wong, John IR - Wong J FIR - Yip, Benita IR - Yip B FIR - Younger, Jaime IR - Younger J FIR - Ainsworth, Jonathan IR - Ainsworth J FIR - Allan, Sris IR - Allan S FIR - Babiker, Abdel IR - Babiker A FIR - Chadwick, David IR - Chadwick D FIR - Delpech, Valerie IR - Delpech V FIR - Dunn, David IR - Dunn D FIR - Fisher, Martin IR - Fisher M FIR - Gazzard, Brian IR - Gazzard B FIR - Gilson, Richard IR - Gilson R FIR - Gompels, Mark IR - Gompels M FIR - Hay, Phillip IR - Hay P FIR - Johnson, Margaret IR - Johnson M FIR - Kegg, Stephen IR - Kegg S FIR - Leen, Clifford IR - Leen C FIR - Orkin, Chloe IR - Orkin C FIR - Palfreeman, Adrian IR - Palfreeman A FIR - Phillips, Andrew IR - Phillips A FIR - Pillay, Deenan IR - Pillay D FIR - Post, Frank IR - Post F FIR - Pritchard, Jillian IR - Pritchard J FIR - Sachikonye, Memory IR - Sachikonye M FIR - Schwenk, Achim IR - Schwenk A FIR - Tariq, Anjum IR - Tariq A FIR - Walsh, John IR - Walsh J FIR - Thornton, Alicia IR - Thornton A FIR - Glabay, Adam IR - Glabay A FIR - Perry, Nicky IR - Perry N FIR - Tilbury, Stuart IR - Tilbury S FIR - Youssef, Elaney IR - Youssef E FIR - Churchill, Duncan IR - Churchill D FIR - Everett, Rhiannon IR - Everett R FIR - Asboe, David IR - Asboe D FIR - Mandalia, Sundhiya IR - Mandalia S FIR - Korat, Hardik IR - Korat H FIR - Taylor, Chris IR - Taylor C FIR - Gleisner, Zachary IR - Gleisner Z FIR - Ibrahim, Fowzia IR - Ibrahim F FIR - Campbell, Lucy IR - Campbell L FIR - Brima, Nataliya IR - Brima N FIR - Williams, Ian IR - Williams I FIR - Youle, Mike IR - Youle M FIR - Lampe, Fiona IR - Lampe F FIR - Smith, Colette IR - Smith C FIR - Tsintas, Rob IR - Tsintas R FIR - Chaloner, Clinton IR - Chaloner C FIR - Hutchinson, Samantha IR - Hutchinson S FIR - Huntington, Susie IR - Huntington S FIR - Mackie, Nicky IR - Mackie N FIR - Winston, Alan IR - Winston A FIR - Weber, Jonathan IR - Weber J FIR - Ramzan, Farhan IR - Ramzan F FIR - Carder, Mark IR - Carder M FIR - Lynch, Janet IR - Lynch J FIR - Hand, James IR - Hand J FIR - de Souza, Carl IR - de Souza C FIR - Munshi, Sajid IR - Munshi S FIR - Miller, Sheila IR - Miller S FIR - Wood, Chris IR - Wood C FIR - Wilson, Alan IR - Wilson A FIR - Morris, Sheila IR - Morris S FIR - Allan, Sue IR - Allan S FIR - Memon, Khurram IR - Memon K FIR - Lewszuk, Adam IR - Lewszuk A FIR - Cope, Emma IR - Cope E FIR - Gibson, Jane IR - Gibson J FIR - Main, Paul IR - Main P FIR - Dhillon, Mandip IR - Dhillon M FIR - Russell-Sharpe, Sarah IR - Russell-Sharpe S FIR - Harte, Andrew IR - Harte A FIR - Clay, Stephen IR - Clay S FIR - Spencer, Hazel IR - Spencer H FIR - Jones, Ron IR - Jones R FIR - Cumming, Shirley IR - Cumming S FIR - Atkinson, Claire IR - Atkinson C FIR - Trevelion, Roy IR - Trevelion R EDAT- 2017/04/26 06:00 MHDA- 2018/05/10 06:00 PMCR- 2017/09/15 CRDT- 2017/04/26 06:00 PHST- 2017/01/17 00:00 [accepted] PHST- 2017/04/26 06:00 [pubmed] PHST- 2018/05/10 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] PHST- 2017/09/15 00:00 [pmc-release] AID - HIV12505 [pii] AID - 10.1111/hiv.12505 [doi] PST - ppublish SO - HIV Med. 2017 Oct;18(9):655-666. doi: 10.1111/hiv.12505. Epub 2017 Apr 24.