PMID- 28440520
OWN - NLM
STAT- MEDLINE
DCOM- 20170908
LR  - 20221207
IS  - 1671-0274 (Print)
IS  - 1671-0274 (Linking)
VI  - 20
IP  - 4
DP  - 2017 Apr 25
TI  - [Effect of laparoscopic sleeve gatrectomy on type 2 diabetes mellitus in obese 
      patients with body mass index less than 40 kg/m(2)].
PG  - 400-404
AB  - OBJECTIVE: To evaluate the effect of laparoscopic sleeve gastrectomy(LSG) on type 
      2 diabetes mellitus (T2DM) in patient with a body mass index(BMI) less than 40 
      kg/m(2). METHODS: Twenty four obese patients with T2DM and BMI less than 40 
      kg/m(2) received LSG between 1 January 2011 and 1 September 2013 at the 
      Department of General Surgery in Chinese PLA General Hospital. The clinical data 
      and 3-year follow-up outcomes regarding weight loss and remission of diabetes 
      were retrospectively analyzed. RESULTS: There were 10 males and 14 females with a 
      median age of 40.8(35 to 48) years. The preoperative body weight and BMI 
      was(99.9+/-15.0) kg and (34.4+/-2.8) kg/m(2), respectively. The median duration of 
      type 2 diabetes was 4.3(2 to 15) years. The preoperative fasting blood glucose 
      and glycosylated hemoglobin(HbAlc) was (11.4+/-1.3) mmol/L and (8.7+/-0.8)%, 
      respectively. All these patients were preoperatively diagnosed as T2DM by the 
      multidisciplinary experts of the surgical treatment team for obesity and diabetes 
      in our center. All these patients were eligible for surgical treatment through 
      the screening and evaluation by the multidisciplinary joint outpatient service. 
      All the procedures were successfully completed without conversion to laparotomy. 
      There were no severe postoperative complications. The mean fasting blood glucose 
      was (6.4+/-1.8) mmol/L, (6.1+/-1.7) mmol/L, (6.0+/-1.5) mmol/L, (5.9+/-1.4) mmol/L and 
      (6.0+/-1.4) mmol/L, respectively, at 6, 9, 12, 24 and 36 months after operation. 
      The mean HbA1c in the same observation intervals was (6.6+/-1.1)%, (6.2+/-1.2)%, 
      (6.1+/-1.2)%, (6.0+/-1.3)% and (6.1+/-1.3)%, respectively. The body weight was 
      (89.4+/-11.4) kg, (86.3+/-10.6) kg, (83.1+/-10.2) kg,(80.6+/-9.8) kg and (81.3+/-10.1) kg, 
      respectively. The corresponding BMI was (30.8+/-1.6) kg/m(2), (29.8+/-1.5) kg/m(2), 
      (28.7+/-1.5) kg/m(2), (27.8+/-1.8) kg/m(2) and (28.1+/-1.8) kg/m(2), respectively. The 
      %EWL was (36.7+/-8.7)%, (47.6+/-12.5)%, (58.8+/-16.4)%, (67.2+/-20.3)% and (64.8+/-21.5)%, 
      respectively. The overall remission rate of diabetes at 6, 9, 12, 24 and 36 
      months was 50.0%(12/24), 79.2%(19/24), 70.8%(17/24), 66.7%(16/24) and 
      62.5%(15/24), respectively. The complete remission rate was 33.3%(8/24), 
      50.0%(12/24), 54.2%(13/24), 45.8%(11/24) and 50.0%(12/24), respectively. For 
      patients with a duration of T2DM shorter than 5 years, the overall remission rate 
      at 9, 12 and 24 months after operation was 10/10, 9/10 and 9/10, respectively, 
      significantly higher than that of patients with a duration of 11-15 years (2/6, 
      2/6 and 2/6, Fisher's exact tests, P=0.008, 0.036 and 0.036, respectively). 
      CONCLUSION: The present study confirms the efficacy of LSG in the treatment of 
      T2DM patients with a BMI less than 40 kg/m(2).
FAU - Guo, Yulin
AU  - Guo Y
AD  - Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Xu, Xiao
AU  - Xu X
AD  - Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Wu, Anjian
AU  - Wu A
AD  - Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Du, Jin
AU  - Du J
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Dong, Guanglong
AU  - Dong G
AD  - Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, 
      China. gldong301@163.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wei Chang Wai Ke Za Zhi
JT  - Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
JID - 101177990
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Bariatric Surgery/*methods
MH  - Blood Glucose/physiology
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*surgery
MH  - Female
MH  - *Gastrectomy
MH  - Glycated Hemoglobin/physiology
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Obesity/*surgery
MH  - Postoperative Complications
MH  - Remission Induction/methods
MH  - Retrospective Studies
MH  - *Treatment Outcome
MH  - *Weight Loss
EDAT- 2017/04/26 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/04/26 06:00
PHST- 2017/04/26 06:00 [entrez]
PHST- 2017/04/26 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
AID - 100001882012 [pii]
PST - ppublish
SO  - Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Apr 25;20(4):400-404.