PMID- 28440866 OWN - NLM STAT- MEDLINE DCOM- 20180515 LR - 20190715 IS - 1530-0277 (Electronic) IS - 0145-6008 (Print) IS - 0145-6008 (Linking) VI - 41 IP - 7 DP - 2017 Jul TI - A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. PG - 1329-1339 LID - 10.1111/acer.13407 [doi] AB - BACKGROUND: Alcohol problems reflect both environmental and genetic characteristics that often operate through endophenotypes like low levels of response (low LRs) to alcohol and higher impulsivity. Relationships of these preexisting characteristics to alcohol problems have been studied, but few analyses have included both low LR and impulsivity in the same model. METHODS: We extracted prospective data from 1,028 participants in the Prospective Youth Sample of the Collaborative Study on the Genetics of Alcoholism (COGA). At Time 1 (age 18), these drinking but non-alcohol-dependent males and females completed the Barratt Impulsivity Scale and the Self-Report of the Effects of Alcohol questionnaire regarding drinks required for effects the first 5 times of drinking (SRE5-LR). Two years later, they reported perceived drinking patterns of peers (PEER), their own alcohol expectancies (EXPECT), and their drinking to cope with stress (COPE). Subsequently, at Time 3, participants reported numbers of up to 11 DSM-IV alcohol criterion items experienced in the 2 years since Time 2 (ALC PROBS). Data were analyzed using structural equation modeling (SEM). RESULTS: In the SEM, Baseline SRE5-LR and impulsivity were weakly related and did not interact in predicting later ALC PROBS. LR was directly linked to Time 3 ALC PROBS and to PEER, but had no direct path to EXPECT, with partial mediation to ALC PROBS through PEER to EXPECT and via COPE. Impulsivity did not relate directly to ALC PROBS or PEER, but was directly related to EXPECT and COPE, with effects on ALC PROBS also operating through EXPECT and COPE. CONCLUSIONS: Low LRs and impulsivity related to Time 3 ALC PROBS through somewhat different paths. Education- and counseling-based approaches to mitigate future alcohol problems may benefit from emphasizing different potential mediators of adverse alcohol outcomes for youth with low LRs versus those with high impulsivity or both characteristics. CI - Copyright (c) 2017 by the Research Society on Alcoholism. FAU - Schuckit, Marc A AU - Schuckit MA AUID- ORCID: 0000-0002-2323-7858 AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Smith, Tom L AU - Smith TL AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Danko, George AU - Danko G AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Anthenelli, Robert AU - Anthenelli R AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Schoen, Lara AU - Schoen L AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Kawamura, Mari AU - Kawamura M AD - Department of Psychiatry, University of California, San Diego, La Jolla, California. FAU - Kramer, John AU - Kramer J AD - Department of Psychiatry, The University of Iowa, Iowa City, Iowa. FAU - Dick, Danielle M AU - Dick DM AD - Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia. FAU - Neale, Zoe AU - Neale Z AD - Department of Psychology, Virginia Commonwealth University, Richmond, Virginia. FAU - Kuperman, Samuel AU - Kuperman S AD - Child Psychiatry Clinic, The University of Iowa, Iowa City, Iowa. FAU - McCutcheon, Vivia AU - McCutcheon V AD - Department of Psychiatry, Washington University, St. Louis, Missouri. FAU - Anokhin, Andrey P AU - Anokhin AP AD - Washington University in Saint Louis School of Medicine, St. Louis, Missouri. FAU - Hesselbrock, Victor AU - Hesselbrock V AD - Department of Psychiatry, University of Connecticut, Farmington, Connecticut. FAU - Hesselbrock, Michie AU - Hesselbrock M AD - Department of Psychiatry, School of Medicine, University of Connecticut, Farmington, Connecticut. FAU - Bucholz, Kathleen AU - Bucholz K AD - Washington University in Saint Louis School of Medicine, St. Louis, Missouri. LA - eng GR - K02 AA018755/AA/NIAAA NIH HHS/United States GR - U10 AA008401/AA/NIAAA NIH HHS/United States PT - Comparative Study PT - Journal Article DEP - 20170524 PL - England TA - Alcohol Clin Exp Res JT - Alcoholism, clinical and experimental research JID - 7707242 SB - IM MH - Adolescent MH - Alcohol-Related Disorders/*etiology/psychology MH - Female MH - Humans MH - *Impulsive Behavior MH - Male MH - Prospective Studies MH - Young Adult PMC - PMC5512427 MID - NIHMS873985 OTO - NOTNLM OT - Alcohol Problems OT - Impulsivity OT - Levels of Response to Alcohol OT - Structural Equation Models EDAT- 2017/04/26 06:00 MHDA- 2018/05/16 06:00 PMCR- 2018/07/01 CRDT- 2017/04/26 06:00 PHST- 2017/03/10 00:00 [received] PHST- 2017/04/18 00:00 [accepted] PHST- 2017/04/26 06:00 [pubmed] PHST- 2018/05/16 06:00 [medline] PHST- 2017/04/26 06:00 [entrez] PHST- 2018/07/01 00:00 [pmc-release] AID - 10.1111/acer.13407 [doi] PST - ppublish SO - Alcohol Clin Exp Res. 2017 Jul;41(7):1329-1339. doi: 10.1111/acer.13407. Epub 2017 May 24.