PMID- 28441982
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180813
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 38
IP  - 3
DP  - 2017 May 1
TI  - 25-Hydroxyvitamin D, biomarkers of eosinophilic inflammation, and airway 
      remodeling in children with newly diagnosed untreated asthma.
PG  - 29-36
LID - 10.2500/aap.2017.38.4026 [doi]
AB  - BACKGROUND: Low 25-hydroxyvitamin D (25[OH]D) and asthma development may be 
      related to airway remodeling and eosinophilia. Periostin is proposed as a key 
      molecule that links remodeling and eosinophilic inflammation. OBJECTIVE: We 
      evaluated the association of 25(OH)D concentration with periostin, peripheral 
      blood eosinophil counts, and immunoglobulin E (IgE) in children with newly 
      diagnosed asthma. METHODS: The study included 150 children: 110 with atopic 
      asthma and 40 constituted a reference group. Fasting blood was collected for cell 
      counts and serum for measurements of 25(OH)D, periostin, IgE, and C-reactive 
      protein (CRP) concentrations. RESULTS: Significantly lower 25(OH)D, elevated IgE 
      concentrations, and eosinophil counts were found in children with asthma compared 
      with the reference group (p = 0.0001). A lower forced expiratory volume in the 
      first second of expiration percentage predicted value was associated with a lower 
      25(OH)D value in children with asthma. The bronchodilator reversibility was 
      inversely related to serum 25(OH)D concentrations (R = -0.45, p = 0.029). The 
      children with asthma and with a 25(OH)D deficient concentration (</=20 ng/mL) had 
      higher concentrations of periostin (p = 0.035) and CRP (p = 0.01) than those with 
      a sufficient 25(OH)D concentration (>/=30 ng/L). Additional analysis revealed 
      statistically significant differences (p = 0.013) when comparing periostin 
      concentrations between subjects with a 25(OH)D deficient concentration (</=20 
      ng/mL) and subjects who did not have a deficient concentration (>20 ng/mL). In 
      individuals with asthma, a 25(OH)D concentration of <30 ng/mL had no impact on 
      eosinophilia, whereas IgE concentrations were associated with increased 
      eosinophils, and the effect of periostin on eosinophilia was small although 
      significant. Multivariate regression, including 25(OH)D concentration, CRP level, 
      eosinophil counts, and sex, accounted for 7% of periostin variation in subjects 
      with asthma. CONCLUSION: In newly diagnosed pediatric asthma, 25(OH)D 
      concentrations revealed a small although significant association with periostin 
      levels but no effect on eosinophilia. A low vitamin D concentration may increase 
      airway remodeling induced by inflammatory mediators, but further clinical studies 
      aimed to explain the causal link between vitamin D insufficiency and asthma are 
      needed.
FAU - Sypniewska, Grazyna
AU  - Sypniewska G
FAU - Krintus, Magdalena
AU  - Krintus M
FAU - Fulgheri, Gabriele
AU  - Fulgheri G
FAU - Siodmiak, Joanna
AU  - Siodmiak J
FAU - Kuligowska-Prusinska, Magdalena
AU  - Kuligowska-Prusinska M
FAU - Stepien-Jaszowska, Beata
AU  - Stepien-Jaszowska B
FAU - Staszak-Kowalska, Radoslawa
AU  - Staszak-Kowalska R
FAU - Zawadzka-Krajewska, Anna
AU  - Zawadzka-Krajewska A
FAU - Kierat, Szymon
AU  - Kierat S
FAU - Bergmann, Katarzyna
AU  - Bergmann K
FAU - Demkow, Urszula
AU  - Demkow U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (POSTN protein, human)
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - *Airway Remodeling
MH  - Asthma/blood/*etiology/pathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Cell Adhesion Molecules/blood
MH  - Child
MH  - Child, Preschool
MH  - Eosinophilia/*complications/diagnosis/pathology
MH  - Eosinophils/pathology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inflammation/etiology
MH  - Male
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/complications
EDAT- 2017/04/27 06:00
MHDA- 2018/02/13 06:00
CRDT- 2017/04/27 06:00
PHST- 2017/04/27 06:00 [entrez]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.2500/aap.2017.38.4026 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2017 May 1;38(3):29-36. doi: 10.2500/aap.2017.38.4026.