PMID- 28442532
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20180521
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 65
IP  - 6
DP  - 2017 Aug
TI  - Anti-inflammatory effects of simvastatin during the resolution phase of 
      experimentally formed venous thrombi.
PG  - 999-1007
LID - 10.1136/jim-2017-000442 [doi]
AB  - Deep venous thrombosis (DVT) is a common vascular disease and is closely linked 
      to inflammation. Over the past decade, the potential antithrombotic effect of 
      statins has been elucidated by clinical studies, primarily through focusing on 
      DVT prevention. The effects of statins on DVT resolution and its underlying 
      mechanisms have been rarely addressed. We established a rabbit model of the 
      inferior vena cava (IVC) venous thrombosis. After 48 hours, the rabbits were 
      treated with saline, heparin, simvastatin, or simvastatin combined with heparin, 
      respectively, for 14 days. The migration of inflammatory cells (neutrophils, 
      monocytes, lymphocytes) in the thrombi and injured venous wall, the plasma levels 
      of interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and P-selectin, and 
      local expression of MCP-1 and P-selectin in the venous wall were evaluated by 
      histology, immunohistochemistry, and ELISA examinations. Our data showed that 
      compared with saline and heparin controls, monotherapy of simvastatin and the 
      adjunctive therapy with simvastatin and heparin significantly improved the 
      thrombus resolution and reduced inflammatory cells migration into the venous 
      wall, the release of the inflammatory cell adhesion molecule (P-selectin), 
      inflammatory chemokine (MCP-1) and pleiotropic proinflammatory cytokines (IL-6) 
      into the blood, and the local expression of P-selectin and MCP-1 in the venous 
      wall. Simvastatin targets anti-inflammatory pathways during the resolution phase 
      of a thrombus, providing a therapeutic potential in DVT resolution and 
      post-thrombotic syndrome prevention.
CI  - Copyright (c) 2017 American Federation for Medical Research.
FAU - Feng, Yaping
AU  - Feng Y
AD  - Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Lei, Bo
AU  - Lei B
AD  - Anesthesia Department, Beijing Haidian Maternal & Child Health Hospital, Beijing, 
      China.
FAU - Zhang, Fuxian
AU  - Zhang F
AD  - Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Niu, Luyuan
AU  - Niu L
AD  - Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Huan
AU  - Zhang H
AD  - Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Mingyi
AU  - Zhang M
AD  - Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170425
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
CIN - J Investig Med. 2018 Feb;66(2):e3. PMID: 29018049
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Cell Movement/drug effects
MH  - Cytokines/blood
MH  - Inflammation/pathology
MH  - Lipids/blood
MH  - Male
MH  - Rabbits
MH  - Simvastatin/pharmacology/*therapeutic use
MH  - Venous Thrombosis/blood/*drug therapy/pathology
OTO - NOTNLM
OT  - Vascular Diseases
COIS- Competing interests: None declared.
EDAT- 2017/04/27 06:00
MHDA- 2018/04/24 06:00
CRDT- 2017/04/27 06:00
PHST- 2017/03/25 00:00 [accepted]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/04/27 06:00 [entrez]
AID - jim-2017-000442 [pii]
AID - 10.1136/jim-2017-000442 [doi]
PST - ppublish
SO  - J Investig Med. 2017 Aug;65(6):999-1007. doi: 10.1136/jim-2017-000442. Epub 2017 
      Apr 25.