PMID- 28442647
OWN - NLM
STAT- MEDLINE
DCOM- 20171031
LR  - 20211110
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 79
IP  - 6
DP  - 2017 Jun 10
TI  - Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and 
      hyperglycemia in the WBN/Kob-Lepr(fa) rat, a new model of type 2 diabetes 
      mellitus.
PG  - 988-991
LID - 10.1292/jvms.17-0136 [doi]
AB  - Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, 
      and these epidemics appear to have emerged largely from changes in daily diet. In 
      the present study, we compared effects of high-fat diet (HFD) and fructose-rich 
      diet (FRD) in WBN/Kob-Lepr(fa) (WBKDF) rats that spontaneously develop obesity, 
      dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD and 
      WBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF 
      rats fed standard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD 
      rats was significantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. 
      The present study demonstrated that the 4-week feeding of HFD and FRD caused 
      diet-induced obesity with a distinct phenotype in the glucose metabolism in WBKDF 
      rats.
FAU - Namekawa, Junichi
AU  - Namekawa J
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Takagi, Yoshiichi
AU  - Takagi Y
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Wakabayashi, Kaoru
AU  - Wakabayashi K
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Nakamura, Yuki
AU  - Nakamura Y
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Watanabe, Ayaka
AU  - Watanabe A
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Nagakubo, Dai
AU  - Nagakubo D
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Shirai, Mitsuyuki
AU  - Shirai M
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
FAU - Asai, Fumitoshi
AU  - Asai F
AD  - Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu 
      University, Sagamihara, Kanagawa 252-5201, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170421
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Blood Glucose)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/etiology
MH  - Diabetes Mellitus, Type 2/physiopathology
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Dyslipidemias/*etiology
MH  - Fructose/*administration & dosage
MH  - Hyperglycemia/*etiology
MH  - Male
MH  - Obesity/*etiology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC5487803
OTO - NOTNLM
OT  - WBN/Kob-Leprfa rat
OT  - diet-induced obesity
OT  - fructose-rich diet
OT  - high-fat diet
OT  - type 2 diabetes
EDAT- 2017/04/27 06:00
MHDA- 2017/11/01 06:00
PMCR- 2017/06/01
CRDT- 2017/04/27 06:00
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2017/11/01 06:00 [medline]
PHST- 2017/04/27 06:00 [entrez]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 17-0136 [pii]
AID - 10.1292/jvms.17-0136 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2017 Jun 10;79(6):988-991. doi: 10.1292/jvms.17-0136. Epub 2017 
      Apr 21.