PMID- 28442889
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1177-5475 (Print)
IS  - 1177-5491 (Electronic)
IS  - 1177-5475 (Linking)
VI  - 11
DP  - 2017
TI  - CUL4A promotes cell invasion in gastric cancer by activating the NF-kappaB signaling 
      pathway.
PG  - 45-53
LID - 10.2147/BTT.S127650 [doi]
AB  - Cullin 4A (CUL4A) overexpression has been reported to be involved in the 
      carcinogenesis and progression of many malignant tumors. However, the role of 
      CUL4A in the progression of gastric cancer (GC) remains unclear. In this study, 
      we explored whether and how CUL4A regulates proinflammatory signaling to promote 
      GC cell invasion. Our results showed that knockdown of CUL4A inhibited GC cell 
      migration and invasion induced by lipopolysaccharide (LPS) stimulation. We also 
      found that both CUL4A and nuclear factor-kappa B (NF-kappaB) protein expressions were 
      enhanced by LPS stimulation in HGC27 GC cell lines. Furthermore, knockdown of 
      CUL4A decreased the protein expression of NF-kappaB and mRNA expression of the 
      downstream genes of the NF-kappaB pathway, such as matrix metalloproteinase (MMP) 2, 
      MMP9, and interleukin-8. Our immunohistochemistry analysis on 50 GC tissue 
      samples also revealed that CUL4A positively correlated with NF-kappaB expression. 
      Taken together, our findings suggest that CUL4A may promote GC cell invasion by 
      regulating the NF-kappaB signaling pathway and could be considered as a potential 
      therapeutic target in patients with GC.
FAU - Gong, Yu
AU  - Gong Y
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
FAU - Xiang, Xiao-Jun
AU  - Xiang XJ
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
FAU - Feng, Miao
AU  - Feng M
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
FAU - Fang, Zi-Ling
AU  - Fang ZL
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
FAU - Xiong, Jian-Ping
AU  - Xiong JP
AD  - Department of Oncology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, Jiangxi, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - New Zealand
TA  - Biologics
JT  - Biologics : targets & therapy
JID - 101321511
PMC - PMC5395274
OTO - NOTNLM
OT  - CUL4A
OT  - NF-kappaB
OT  - gastric cancer
OT  - invasion
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/04/27 06:00
MHDA- 2017/04/27 06:01
PMCR- 2017/04/12
CRDT- 2017/04/27 06:00
PHST- 2017/04/27 06:00 [entrez]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2017/04/27 06:01 [medline]
PHST- 2017/04/12 00:00 [pmc-release]
AID - btt-11-045 [pii]
AID - 10.2147/BTT.S127650 [doi]
PST - epublish
SO  - Biologics. 2017 Apr 12;11:45-53. doi: 10.2147/BTT.S127650. eCollection 2017.