PMID- 28444660 OWN - NLM STAT- MEDLINE DCOM- 20180405 LR - 20180405 IS - 1439-3646 (Electronic) IS - 0947-7349 (Linking) VI - 125 IP - 7 DP - 2017 Jul TI - Effects of Cycling and Exergaming on Neurotrophic Factors in Elderly Type 2 Diabetic Men - A Preliminary Investigation. PG - 436-440 LID - 10.1055/s-0043-103967 [doi] AB - Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing neurodegenerative diseases. There is growing evidence that repeated exercise-induced transient increases in neurotrophic factors can augment neurogenesis and neuroplasticity. This pilot study compares the effects of 30-min submaximal cycling with those of exergaming (combining exercise and video gaming) at the same duration and same rating of perceived exertion (BORG RPE: 14-15) on serum neurotrophic factors in 8 elderly non-insulin-dependent T2DM patients (71+/-4 years) (2x2 crossover design). Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF)-1 levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Heart rates were almost equal during cycling and exergaming, while lactate values were significantly higher during cycling (cycling versus exergaming: 3.7+/-1.1 versus 2.5+/-1.2 mmol/l, p<0.05). BDNF and VEGF levels were increased significantly post-cycling (+20%,+14%, p<0.05). No other significant pre-post changes were evident. This study demonstrates that acute exercise can increase neurotrophic factors (BDNF, VEGF) in elderly T2DM patients, depending on exercise mode. CI - (c) Georg Thieme Verlag KG Stuttgart . New York. FAU - Brinkmann, Christian AU - Brinkmann C AD - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Schafer, Leonie AU - Schafer L AD - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Masoud, Magd AU - Masoud M AD - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Latsch, Joachim AU - Latsch J AD - Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Lay, Daniel AU - Lay D AD - Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Bloch, Wilhelm AU - Bloch W AD - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. FAU - Brixius, Klara AU - Brixius K AD - Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20170425 PL - Germany TA - Exp Clin Endocrinol Diabetes JT - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JID - 9505926 RN - 0 (Nerve Growth Factors) RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Aged MH - *Bicycling MH - Cross-Over Studies MH - Diabetes Mellitus, Type 2/*blood/*physiopathology MH - *Exercise MH - Humans MH - Lactic Acid MH - Male MH - Nerve Growth Factors/*blood MH - Pilot Projects COIS- Conflict of interest: The authors have no conflict of interest to disclose. EDAT- 2017/04/27 06:00 MHDA- 2018/04/06 06:00 CRDT- 2017/04/27 06:00 PHST- 2017/04/27 06:00 [pubmed] PHST- 2018/04/06 06:00 [medline] PHST- 2017/04/27 06:00 [entrez] AID - 10.1055/s-0043-103967 [doi] PST - ppublish SO - Exp Clin Endocrinol Diabetes. 2017 Jul;125(7):436-440. doi: 10.1055/s-0043-103967. Epub 2017 Apr 25.