PMID- 28444966
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20210109
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 40
IP  - 8
DP  - 2017 Aug
TI  - Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling 
      pathway and risk or prognosis of perimenopausal coronary artery disease.
PG  - 597-604
LID - 10.1002/clc.22708 [doi]
AB  - BACKGROUND: Mitogen-activated protein kinase-1 (MAPK1), as well as its downstream 
      factors of hypoxia-inducible factor-1 (HIF-1) and heme oxygenase-1 (HO-1), have 
      been documented to be involved in modulating development of coronary artery 
      disease (CAD). HYPOTHESIS: Genetic mutations within the MAPK1/HIF-1/HO-1 
      signaling pathway could alter the risk of perimenopausal CAD in Chinese patients. 
      METHODS: Peripheral blood samples were gathered from 589 CAD patients and 860 
      healthy controls, and 12 potential single-nucleotide polymorphisms (SNPs) were 
      obtained from HapMap database and previously published studies. Genotyping of 
      SNPs was implemented with the TaqMan SNP Genotyping Assays. Odds ratios (OR) and 
      95% confidence intervals (CI) were utilized to evaluate the correlations between 
      SNPs and CAD risk. RESULTS: Regarding MAPK1 , rs6928 (OR: 1.71, 95% CI: 
      1.47-1.98, P < 0.05), rs9340 (OR: 0.85, 95% CI: 0.73-0.99, P < 0.05), and 
      rs11913721 (OR: 0.70, 95% CI: 0.52-0.95, P < 0.05) were remarkably associated 
      with susceptibility to perimenopausal CAD. Of these, rs9340 and rs11913721 were 
      also regarded as protective factors for perimenopausal CAD patients. Moreover, 
      results of HIF-1 indicated noticeable correlations between combined SNPs of 
      rs1087314 and rs2057482 and risk of perimenopausal CAD (OR: 1.24, 95% CI: 
      1.01-1.53, P < 0.05; and OR: 0.71, 95% CI: 0.55-0.91, P < 0.05, respectively). 
      Nonetheless, rs2071746 in HO-1 was found to be only associated with 
      perimenopausal CAD risk (OR: 0.67, 95% CI: 0.58-0.78, P < 0.05). CONCLUSIONS: The 
      genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF-1 (rs1087314, 
      rs2057482), and HO-1 (rs2071746) could alter susceptibility to perimenopausal CAD 
      in this Chinese population.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Guo, Nan
AU  - Guo N
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, P. R. China.
FAU - Zhang, Nan
AU  - Zhang N
AUID- ORCID: 0000-0002-4713-0908
AD  - Department of Cardiothoracic Surgery, Cangzhou Central Hospital, Hebei Medical 
      University, Cangzhou, P. R. China.
FAU - Yan, Liqiu
AU  - Yan L
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, P. R. China.
FAU - Cao, Xufen
AU  - Cao X
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, P. R. China.
FAU - Wang, Jiawang
AU  - Wang J
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, P. R. China.
FAU - Wang, Yunfei
AU  - Wang Y
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20170426
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - EC 1.14.14.18 (HMOX1 protein, human)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 2.7.11.24 (MAPK1 protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
SB  - IM
MH  - Chi-Square Distribution
MH  - China
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnostic imaging/enzymology/*genetics
MH  - Coronary Stenosis/diagnostic imaging/enzymology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Heme Oxygenase-1/*genetics
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*genetics
MH  - Mitogen-Activated Protein Kinase 1/*genetics
MH  - Odds Ratio
MH  - *Perimenopause
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Signal Transduction/*genetics
PMC - PMC6490459
OTO - NOTNLM
OT  - Gene-Gene Interaction
OT  - MAPK1/HIF-1/HO-1 Signaling
OT  - Perimenopausal CAD
OT  - Single-Nucleotide Polymorphism
OT  - Susceptibility
COIS- The authors declare no potential conflicts of interest.
EDAT- 2017/04/27 06:00
MHDA- 2018/05/08 06:00
PMCR- 2017/04/26
CRDT- 2017/04/27 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/04/27 06:00 [entrez]
PHST- 2017/04/26 00:00 [pmc-release]
AID - CLC22708 [pii]
AID - 10.1002/clc.22708 [doi]
PST - ppublish
SO  - Clin Cardiol. 2017 Aug;40(8):597-604. doi: 10.1002/clc.22708. Epub 2017 Apr 26.