PMID- 28445606
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20180509
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 105
IP  - 9
DP  - 2017 Sep
TI  - Structural and biological properties of thermosensitive chitosan-graphene hybrid 
      hydrogels for sustained drug delivery applications.
PG  - 2381-2390
LID - 10.1002/jbm.a.36096 [doi]
AB  - Chitosan has the ability to make injectable thermosensitive hydrogels which has 
      been highly investigated for drug delivery applications. The addition of 
      nanoparticles is one way to increase the mechanical strength of thermosensitive 
      chitosan hydrogel and subsequently and control the burst release of drug. 
      Graphene nanoparticles have shown unique mechanical, optical and electrical 
      properties which can be exploited for biomedical applications, especially in drug 
      delivery. This study, have focused on the mechanical properties of a 
      thermosensitive and injectable hybrid chitosan hydrogel incorporated with 
      graphene nanoparticles. Scanning electron microscope (SEM), Fourier transform 
      infrared (FTIR) spectroscopy, Raman spectroscopy, and X-ray diffraction (XRD) 
      have been used for morphological and chemical characterization of graphene 
      infused chitosan hydrogels. The cell viability and cytotoxicity of 
      graphene-contained hydrogels were analyzed using the alamarBlue((R)) technique. 
      In-vitro methotrexate (MTX) release was investigated from MTX-loaded hybrid 
      hydrogels as well. As a last step, to evaluate their efficiency as a cancer 
      treatment delivery system, an in vitro anti-tumor test was also carried out using 
      MCF-7 breast cancer cell lines. Results confirmed that a thermosensitive 
      chitosan-graphene hybrid hydrogel can be used as a potential breast cancer 
      therapy system for controlled delivery of methotrexate. (c) 2017 Wiley Periodicals, 
      Inc. J Biomed Mater Res Part A: 105A: 2381-2390, 2017.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Saeednia, Leyla
AU  - Saeednia L
AD  - Department of Mechanical Engineering, Wichita State University, 1845 Fairmount 
      Street, Wichita, Kansas, 67260.
FAU - Yao, Li
AU  - Yao L
AD  - Department of Biological Sciences, Wichita State University, 1845 Fairmount 
      Street, Wichita, Kansas, 67260.
FAU - Berndt, Marcus
AU  - Berndt M
AD  - Department of Biological Sciences, Wichita State University, 1845 Fairmount 
      Street, Wichita, Kansas, 67260.
FAU - Cluff, Kim
AU  - Cluff K
AD  - Department of Biomedical Engineering, Wichita State University, 1845 Fairmount 
      Street, Wichita, Kansas, 67260.
FAU - Asmatulu, Ramazan
AU  - Asmatulu R
AD  - Department of Mechanical Engineering, Wichita State University, 1845 Fairmount 
      Street, Wichita, Kansas, 67260.
LA  - eng
PT  - Journal Article
DEP - 20170522
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Hydrogels)
RN  - 7782-42-5 (Graphite)
RN  - 9012-76-4 (Chitosan)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Cell Death/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Chitosan/*chemistry
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Graphite/*chemistry
MH  - Hydrogels/*chemistry
MH  - Kinetics
MH  - Methotrexate/pharmacology
MH  - Mice
MH  - Spectroscopy, Fourier Transform Infrared
MH  - *Temperature
OTO - NOTNLM
OT  - chitosan
OT  - drug delivery
OT  - graphene
OT  - injectable hydrogels
EDAT- 2017/04/27 06:00
MHDA- 2018/05/10 06:00
CRDT- 2017/04/27 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2017/04/06 00:00 [revised]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PHST- 2017/04/27 06:00 [entrez]
AID - 10.1002/jbm.a.36096 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2017 Sep;105(9):2381-2390. doi: 10.1002/jbm.a.36096. Epub 
      2017 May 22.