PMID- 28445779
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180423
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 242
DP  - 2017 Aug
TI  - The acute cardiorespiratory effects of centrally injected arachidonic acid; the 
      mediation of prostaglandin E, D and F(2alpha).
PG  - 117-124
LID - S1569-9048(16)30277-4 [pii]
LID - 10.1016/j.resp.2017.04.006 [doi]
AB  - Arachidonic acid (AA), which is released from synaptic membrane phospholipid by 
      neuroreceptor-initiated activation of phospholipase A(2), is abundant in the 
      brain and works as a neurotransmitter and/or neuromodulator in the central 
      nervous system. Recently we reported that centrally injected AA generated pressor 
      and hyperventilation effects by activating thromboxane A(2) (TXA(2)) signaling 
      pathway. The present study was designed to investigate the mediation of other 
      metabolites of AA such as prostaglandin (PG) D, PGE and PGF(2alpha) alongside TXA(2) 
      in the AA-evoked cardiorespiratory effects in anaesthetized rats. 
      Intracerebroventricular (i.c.v.) administration of AA caused pressor, bradycardic 
      and hyperventilation responses by increasing pO(2) and decreasing pCO(2) in adult 
      male anaesthetized Sprague Dawley rats. Pretreatment (i.c.v) with different doses 
      of DP/EP prostanoid receptor antagonist, AH6809 or FP prostanoid receptor 
      antagonist, PGF(2alpha) dimethylamine partially blocked the cardiorespiratory and 
      blood gas changes induced by AA. In conclusion, these data plainly report that 
      central PGD, PGE or PGF(2alpha) might mediate, at least partly, centrally 
      administered AA-evoked cardiorespiratory and blood gas responses.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Erkan, Leman Gizem
AU  - Erkan LG
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey.
FAU - Altinbas, Burcin
AU  - Altinbas B
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey.
FAU - Guvenc, Gokcen
AU  - Guvenc G
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey.
FAU - Aydin, Begum
AU  - Aydin B
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey.
FAU - Niaz, Nasir
AU  - Niaz N
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey.
FAU - Yalcin, Murat
AU  - Yalcin M
AD  - Department of Physiology, Faculty of Veterinary Medicine, Uludag University, 
      Bursa, 16059, Turkey. Electronic address: mrtylcn75@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170423
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Prostaglandins D)
RN  - 0 (Prostaglandins E)
RN  - 0 (Prostaglandins F)
RN  - 0 (Receptors, Prostaglandin)
RN  - 0 (Respiratory System Agents)
RN  - 0 (Xanthones)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 33458-93-4 (6-isopropoxy-9-oxoxanthene-2-carboxylic acid)
RN  - 57576-52-0 (Thromboxane A2)
SB  - IM
MH  - Animals
MH  - Arachidonic Acid/*pharmacology
MH  - Blood Gas Analysis
MH  - Blood Pressure/drug effects/physiology
MH  - Cardiovascular Agents/*pharmacology
MH  - Infusions, Intraventricular
MH  - Male
MH  - Prostaglandins D/*metabolism
MH  - Prostaglandins E/*metabolism
MH  - Prostaglandins F/*metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Prostaglandin/antagonists & inhibitors/metabolism
MH  - Respiration/drug effects
MH  - Respiratory System Agents/*pharmacology
MH  - Thromboxane A2/metabolism
MH  - Time Factors
MH  - Xanthones/pharmacology
OTO - NOTNLM
OT  - Arachidonic acid
OT  - Heart rate
OT  - Intracerebroventricular
OT  - Mean blood pressure
OT  - PGD
OT  - PGE
OT  - PGF2alpha
OT  - Partial carbon dioxide pressure
OT  - Partial oxygen pressure
OT  - Respiratory minute ventilation
OT  - Respiratory rate
OT  - Tidal volume
EDAT- 2017/04/27 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/04/27 06:00
PHST- 2016/11/16 00:00 [received]
PHST- 2017/04/17 00:00 [revised]
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/04/27 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/04/27 06:00 [entrez]
AID - S1569-9048(16)30277-4 [pii]
AID - 10.1016/j.resp.2017.04.006 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2017 Aug;242:117-124. doi: 10.1016/j.resp.2017.04.006. 
      Epub 2017 Apr 23.