PMID- 28447512
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20211204
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Print)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Centella asiatica enhances hepatic antioxidant status and regulates hepatic 
      inflammatory cytokines in type 2 diabetic rats.
PG  - 1671-1678
LID - 10.1080/13880209.2017.1318293 [doi]
AB  - CONTEXT: Neutralizing the over-activation of oxidative stress and inflammation 
      remains an important goal in the management of type 2 diabetes mellitus (T2DM). 
      Centella asiatica (L.) Urban (Apiaceae) (CA) has been used in traditional 
      folklore in Africa and Asia to treat various ailments including diabetes. 
      OBJECTIVE: We investigated the hepatic antioxidant and anti-inflammatory 
      potential of methanol extract of CA leaves in T2DM. MATERIALS AND METHODS: T2DM 
      was induced in male Sprague-Dawley rats with 10% fructose in drinking water for 
      14 days followed by a single intraperitoneal injection of streptozotocin 
      (40 mg/kg b.wt). Hepatic oxidant/antioxidant status was assessed by measuring the 
      concentrations of malondialdehyde (MDA), ferric reducing antioxidant power 
      (FRAP), oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant 
      capacity (TEAC), reduced glutathione (GSH) and activities of glutathione 
      S-transferase (GST) and glutathione peroxidase (GPX). The concentrations of 
      cytokines IL-1beta, IL-4, IL-6, IL-10, MCP-1 and TNF-alpha in the liver were determined. 
      RESULTS: Diabetes increased MDA formed (47%) and reduced FRAP (20%), TEAC (15%), 
      GSH levels (32%), significantly; decreased GST and GPX activities in the liver 
      and elevated levels of cytokines studied. Treatment of diabetic rats with 
      500 mg/kg b.wt CA for 14 days decreased MDA (44%); elevated FRAP (15%) and GSH 
      (131%) levels and increased the activities of GST and GPX by 16%. Hepatic 
      concentrations of IL-1beta, MCP-1 and TNF-alpha in DCA group were reduced to 68%, 75% 
      and 63% of DC values, respectively. CONCLUSIONS: The antioxidant and 
      anti-inflammatory properties of CA may protect tissues such as the liver from 
      diabetes-induced oxidative damage.
FAU - Oyenihi, Ayodeji B
AU  - Oyenihi AB
AD  - a Discipline of Biochemistry , School of Life Sciences, University of 
      KwaZulu-Natal , Durban , South Africa.
FAU - Chegou, Novel N
AU  - Chegou NN
AD  - b DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC 
      Centre for Tuberculosis Research, Division of Molecular Biology and Human 
      Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health 
      Sciences , Stellenbosch University , Tygerberg , South Africa.
FAU - Oguntibeju, Oluwafemi O
AU  - Oguntibeju OO
AD  - c Department of Biomedical Sciences, Phytomedicine and Diabetes Research Group , 
      Oxidative Stress Research Centre, Cape Peninsula University of Technology , 
      Bellville , South Africa.
FAU - Masola, Bubuya
AU  - Masola B
AD  - a Discipline of Biochemistry , School of Life Sciences, University of 
      KwaZulu-Natal , Durban , South Africa.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Antioxidants)
RN  - 0 (Centella asiatica extract)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Centella
MH  - Cytokines/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/physiopathology
MH  - Diabetes Mellitus, Type 2/*drug therapy/physiopathology
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Inflammation/drug therapy/pathology
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Streptozocin
MH  - Triterpenes/*pharmacology
PMC - PMC6130484
OTO - NOTNLM
OT  - Apiaceae
OT  - Diabetes
OT  - lipids
OT  - liver
OT  - oxidative stress
EDAT- 2017/04/28 06:00
MHDA- 2017/10/31 06:00
PMCR- 2017/04/27
CRDT- 2017/04/28 06:00
PHST- 2017/04/28 06:00 [entrez]
PHST- 2017/04/28 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2017/04/27 00:00 [pmc-release]
AID - 1318293 [pii]
AID - 10.1080/13880209.2017.1318293 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1671-1678. doi: 10.1080/13880209.2017.1318293.