PMID- 28448518
OWN - NLM
STAT- MEDLINE
DCOM- 20170906
LR  - 20220321
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Clinical efficacy and safety of mesenchymal stem cell transplantation for 
      osteoarthritis treatment: A meta-analysis.
PG  - e0175449
LID - 10.1371/journal.pone.0175449 [doi]
LID - e0175449
AB  - PURPOSE: The aim of this study was to evaluate the therapeutic efficacy and 
      safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee 
      osteoarthritis (OA). MATERIALS: We performed a meta-analysis of relevant 
      published clinical studies. An electronic search was conducted for randomized 
      controlled trials (RCTs) of MSC-based therapy in knee OA. The visual analogue 
      scale (VAS), International Knee Documentation Committee (IKDC) form, Western 
      Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne 
      algofunctional indices (Lequesne), Lysholm knee scale (Lysholm), Tegner activity 
      scale (Tegner) and adverse events (AEs) were evaluated. RESULTS: Eleven eligible 
      trials with 582 knee OA patients were included in the present meta-analysis. We 
      demonstrated that MSC treatment could significantly decrease VAS and increase 
      IKDC scoresafter a 24-month follow-up compared with controls (P<0.05). MSC 
      therapy also showed significant decreases in WOMAC and Lequesne scores after the 
      12-month follow-up (P<0.01). Analysis of Lysholm (24-month) and Tegner (12- and 
      24-month) scores also demonstrated favorable results for MSC treatment (P<0.05). 
      CONCLUSION: Overall, MSC transplantation treatment was shown to be safe and has 
      great potential as an efficacious clinical therapy for patients with knee OA.
FAU - Yubo, Ma
AU  - Yubo M
AD  - Department of Orthopaedics, Hongqi Hospital, Mudanjiang Medical University, 
      Mudanjiang City, Heilongjiang Province, China.
FAU - Yanyan, Li
AU  - Yanyan L
AD  - Department of Neurology, The Second People Hospital of Mudanjiang, Mudanjiang 
      City, Heilongjiang Province, China.
FAU - Li, Li
AU  - Li L
AD  - Department of Basic Medicine, Mudanjiang Medical University, Mudanjiang City, 
      Heilongjiang Province, China.
FAU - Tao, Sun
AU  - Tao S
AD  - Department of Radiology, Hongqi Hospital, Mudanjiang Medical University, 
      Mudanjiang City, Heilongjiang Province, China.
FAU - Bo, Lin
AU  - Bo L
AD  - Department of Orthopaedics, Hongqi Hospital, Mudanjiang Medical University, 
      Mudanjiang City, Heilongjiang Province, China.
FAU - Lin, Chen
AU  - Lin C
AD  - Department of Orthopaedics, The 2nd Affiliated Hospital of Harbin Medical 
      University, Harbin City, Heilongjiang Province, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170427
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*adverse effects/*methods
MH  - Osteoarthritis, Knee/*surgery
MH  - *Safety
PMC - PMC5407776
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/04/28 06:00
MHDA- 2017/09/07 06:00
PMCR- 2017/04/27
CRDT- 2017/04/28 06:00
PHST- 2016/04/23 00:00 [received]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/04/28 06:00 [entrez]
PHST- 2017/04/28 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/04/27 00:00 [pmc-release]
AID - PONE-D-16-13940 [pii]
AID - 10.1371/journal.pone.0175449 [doi]
PST - epublish
SO  - PLoS One. 2017 Apr 27;12(4):e0175449. doi: 10.1371/journal.pone.0175449. 
      eCollection 2017.