PMID- 28448868 OWN - NLM STAT- MEDLINE DCOM- 20180326 LR - 20180326 IS - 1950-6007 (Electronic) IS - 0753-3322 (Linking) VI - 91 DP - 2017 Jul TI - Protective effects of Teucrium polium aqueous extract and ascorbic acid on hematological and some biochemical parameters against carbon tetrachloride (CCl(4)) induced toxicity in rats. PG - 43-48 LID - S0753-3322(17)31112-5 [pii] LID - 10.1016/j.biopha.2017.04.071 [doi] AB - Herbal drugs play a crucial function to protect organisms from the toxic effect of some compounds. The present study was designed to evaluate the protective effects of Teucrium Polium (TP) aqueous extract and vitamin C (Vit C) against carbon tetrachloride (CCl(4)) which induced toxicity in rats. Male albino Wistar rats were divided into six groups: group I was used as controls, group II received CCl(4) in olive oil (0.5ml/kg) by gavage, and group III received CCl(4) in olive oil (0.5ml/kg) by gavage after three days of receiving TP (5g/l), orally, for seven days; Group IV received TP (5g/l) alone, orally, for seven days, Group V received CCl(4) in olive oil (0.5ml/kg) by gavage after three days of receiving Vit C (250mg/kg) by intramuscular injection and Group VI received Vit C (250mg/kg) alone by intramuscular injection, for day seven. Some biochemical and hematological parameters were investigated. Our results showed that the administration of CCl(4) caused hepatotoxicity as monitored by the significant increase in the levels of hepatic markers enzymes (lactate dehydrogenase (LDH), Alkaline phosphatase (PAL), total bilirubin (TB) and Gamma glutamyl transferase (gammaGT) levels) and a decrease in hematological parameters such as white blood cell (WBC), red blood cell count (RBC), mean corpuscular hemoglobin concentration (MCHC) and blood platelet count (PLT). Treatment with TP or Vit C appeared to be effective against hematotoxic and the liver changes induced by CCl(4), as evidenced by the improvement of the parameters cited above. The CCl(4)-treated group demonstrated a significant increase of malondialdehyde (MDA) levels in erythrocytes thus causing a reduction in antioxidant defense system. Pretreatment with TP or Vit C improved the biochemical analyses, hematological parameters, and antioxidant defense system. CI - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved. FAU - Rahmouni, Fatma AU - Rahmouni F AD - Laboratory of Histology, Medicine Faculty of Sfax University, 3029 Sfax, Tunisia. Electronic address: Fatma_Jdaida@yahoo.fr. FAU - Hamdaoui, Latifa AU - Hamdaoui L AD - Laboratory of Histology, Medicine Faculty of Sfax University, 3029 Sfax, Tunisia. FAU - Badraoui, Riadh AU - Badraoui R AD - Laboratory of Histology, Medicine Faculty of Sfax University, 3029 Sfax, Tunisia. FAU - Rebai, Tarek AU - Rebai T AD - Laboratory of Histology, Medicine Faculty of Sfax University, 3029 Sfax, Tunisia. LA - eng PT - Journal Article DEP - 20170523 PL - France TA - Biomed Pharmacother JT - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JID - 8213295 RN - 0 (Antioxidants) RN - 0 (Biomarkers) RN - 0 (Plant Extracts) RN - 0 (Protective Agents) RN - 059QF0KO0R (Water) RN - CL2T97X0V0 (Carbon Tetrachloride) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Animals MH - Antioxidants/pharmacology MH - Ascorbic Acid/*pharmacology MH - Biomarkers/blood MH - Carbon Tetrachloride/*toxicity MH - Erythrocytes/drug effects/metabolism MH - Lipid Peroxidation/drug effects MH - Male MH - Phytotherapy MH - Plant Extracts/*pharmacology MH - Protective Agents/*pharmacology MH - Rats, Wistar MH - Teucrium/*chemistry MH - Water/*chemistry OTO - NOTNLM OT - Carbon tetrachloride OT - Erythrocyte OT - Hematology OT - Oxidative stress EDAT- 2017/04/28 06:00 MHDA- 2018/03/27 06:00 CRDT- 2017/04/28 06:00 PHST- 2017/03/10 00:00 [received] PHST- 2017/03/31 00:00 [revised] PHST- 2017/04/17 00:00 [accepted] PHST- 2017/04/28 06:00 [pubmed] PHST- 2018/03/27 06:00 [medline] PHST- 2017/04/28 06:00 [entrez] AID - S0753-3322(17)31112-5 [pii] AID - 10.1016/j.biopha.2017.04.071 [doi] PST - ppublish SO - Biomed Pharmacother. 2017 Jul;91:43-48. doi: 10.1016/j.biopha.2017.04.071. Epub 2017 May 23.