PMID- 28448933
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20181202
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 598
DP  - 2017 Nov 15
TI  - In vitro bioaccessibility of copper azole following simulated dermal transfer 
      from pressure-treated wood.
PG  - 413-420
LID - S0048-9697(17)30758-1 [pii]
LID - 10.1016/j.scitotenv.2017.03.227 [doi]
AB  - Micronized copper azole (MCA) and micronized copper quaternary (MCQ) are the 
      latest wood preservatives to replace the liquid alkaline copper and chromated 
      copper arsenate preservatives due to concerns over the toxicity or lack of 
      effectiveness of the earlier formulations. Today, the use of MCA has become 
      abundant in the wood preservative industry with approximately 38millionlbs of 
      copper carbonate being used to treat lumber each year. Despite this widespread 
      usage, little information is available on the bioaccessibility of this 
      preservative upon gastrointestinal exposure. Using a simulated 
      hand-to-mouth/gastric system exposure study we investigated several types of 
      commercially available copper-treated lumber products as-purchased and after 
      exposure to outdoor weathering conditions. Soluble and particulate fractions of 
      copper were measured after transfer to and release from surface wipes passed 
      along copper-treated lumber and exposed to synthetic stomach fluid (SSF, pH1.5) 
      or deionized (DI) water. Wipes passed along new boards contained greater amounts 
      of copper than wipes from weathered boards. The total copper recovered from the 
      wipes after microwave extraction varied among the different wood types. For all 
      wood types the copper released into SSF was more soluble than what was soluble in 
      DI water. The data suggest that copper from treated wood is highly bioaccessible 
      in SSF regardless of wood type and weathering condition.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Griggs, Jennifer L
AU  - Griggs JL
AD  - Oak Ridge Institute for Science and Education (ORISE) Research Participant, 109 
      TW Alexander Dr., RTP, NC 27711, USA. Electronic address: 
      Griggs.jennifer@epa.gov.
FAU - Rogers, Kim R
AU  - Rogers KR
AD  - U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
FAU - Nelson, Clay
AU  - Nelson C
AD  - U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
FAU - Luxton, Todd
AU  - Luxton T
AD  - U.S. Environmental Protection Agency, Cincinnati, OH 45220, USA.
FAU - Platten, William E 3rd
AU  - Platten WE 3rd
AD  - U.S. Environmental Protection Agency, Cincinnati, OH 45220, USA.
FAU - Bradham, Karen D
AU  - Bradham KD
AD  - U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
LA  - eng
GR  - EPA999999/Intramural EPA/United States
PT  - Journal Article
DEP - 20170425
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Arsenates)
RN  - 0 (Azoles)
RN  - 059QF0KO0R (Water)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Arsenates
MH  - Azoles/*pharmacokinetics
MH  - Copper/*pharmacokinetics
MH  - Eating
MH  - Environmental Exposure/*analysis
MH  - Humans
MH  - Pressure
MH  - Water
MH  - Wood/*chemistry
PMC - PMC6145065
MID - NIHMS983359
OTO - NOTNLM
OT  - Bioaccessibility
OT  - Exposure
OT  - Micronized copper
OT  - Stomach fluid
OT  - Wood preservative
EDAT- 2017/04/28 06:00
MHDA- 2018/08/01 06:00
PMCR- 2018/11/15
CRDT- 2017/04/28 06:00
PHST- 2017/01/30 00:00 [received]
PHST- 2017/03/24 00:00 [revised]
PHST- 2017/03/24 00:00 [accepted]
PHST- 2017/04/28 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/04/28 06:00 [entrez]
PHST- 2018/11/15 00:00 [pmc-release]
AID - S0048-9697(17)30758-1 [pii]
AID - 10.1016/j.scitotenv.2017.03.227 [doi]
PST - ppublish
SO  - Sci Total Environ. 2017 Nov 15;598:413-420. doi: 10.1016/j.scitotenv.2017.03.227. 
      Epub 2017 Apr 25.