PMID- 28449608
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20180509
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 25
IP  - 6
DP  - 2017 Sep
TI  - Primary Pulmonary Myxoid Sarcoma: A Newly Described Entity-Report of a Case and 
      Review of the Literature.
PG  - 518-525
LID - 10.1177/1066896917706413 [doi]
AB  - Primary pulmonary myxoid sarcoma (PPMS) is a recently described, exceedingly rare 
      low-grade lung sarcoma that tends to present in young females as an endobronchial 
      mass and shows evidence of an EWSR1- CREB1 fusion. Herein, we present a case of 
      PPMS with fluorescence in situ hybridization (FISH) analysis for EWSR1 and CREB1 
      rearrangements. An 80-year-old woman presented with an endobronchial, 
      multinodular tumor exhibiting spindle, ovoid and epithelioid cells arranged in 
      reticular/lattice-like and alveolar-like patterns in a myxoid background. The 
      tumor showed focal epithelial membrane antigen immunoreactivity as well as an 
      Alcian blue-positive stroma that was sensitive to digestion with hyaluronidase. 
      EWSR1 and CREB1 rearrangements were detected by break-apart FISH probes. The 
      patient showed persistence of disease 36 months after diagnosis and was 
      discharged to hospice care. We contribute with a report of an additional case of 
      this very unusual entity and perform a brief review of the literature published 
      so far on the subject.
FAU - Prieto-Granada, Carlos N
AU  - Prieto-Granada CN
AD  - 1 The University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Ganim, Rose B
AU  - Ganim RB
AD  - 2 Baystate Medical Center-University of Massachusetts Medical School Regional 
      Campus, Springfield, MA, USA.
FAU - Zhang, Lei
AU  - Zhang L
AD  - 3 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Antonescu, Cristina
AU  - Antonescu C
AD  - 3 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Mueller, James
AU  - Mueller J
AD  - 2 Baystate Medical Center-University of Massachusetts Medical School Regional 
      Campus, Springfield, MA, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20170428
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (CREB1 protein, human)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
SB  - IM
MH  - Aged, 80 and over
MH  - Cyclic AMP Response Element-Binding Protein/genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/genetics/*pathology
MH  - RNA-Binding Protein EWS/genetics
MH  - Sarcoma/genetics/*pathology
OTO - NOTNLM
OT  - EWSR1-CREB1
OT  - fluorescence in situ hybridization
OT  - lung sarcoma
OT  - primary pulmonary myxoid sarcoma
EDAT- 2017/04/30 06:00
MHDA- 2018/05/10 06:00
CRDT- 2017/04/29 06:00
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PHST- 2017/04/29 06:00 [entrez]
AID - 10.1177/1066896917706413 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2017 Sep;25(6):518-525. doi: 10.1177/1066896917706413. Epub 
      2017 Apr 28.