PMID- 28449694
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20181113
IS  - 1474-760X (Electronic)
IS  - 1474-7596 (Print)
IS  - 1474-7596 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Apr 27
TI  - The MHC locus and genetic susceptibility to autoimmune and infectious diseases.
PG  - 76
LID - 10.1186/s13059-017-1207-1 [doi]
LID - 76
AB  - In the past 50 years, variants in the major histocompatibility complex (MHC) 
      locus, also known as the human leukocyte antigen (HLA), have been reported as 
      major risk factors for complex diseases. Recent advances, including large genetic 
      screens, imputation, and analyses of non-additive and epistatic effects, have 
      contributed to a better understanding of the shared and specific roles of MHC 
      variants in different diseases. We review these advances and discuss the 
      relationships between MHC variants involved in autoimmune and infectious 
      diseases. Further work in this area will help to distinguish between alternative 
      hypotheses for the role of pathogens in autoimmune disease development.
FAU - Matzaraki, Vasiliki
AU  - Matzaraki V
AUID- ORCID: 0000-0002-5852-6801
AD  - Department of Genetics, University of Groningen, University Medical Center 
      Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
FAU - Kumar, Vinod
AU  - Kumar V
AD  - Department of Genetics, University of Groningen, University Medical Center 
      Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
FAU - Wijmenga, Cisca
AU  - Wijmenga C
AD  - Department of Genetics, University of Groningen, University Medical Center 
      Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands. c.wijmenga@umcg.nl.
AD  - Department of Immunology, KG Jebsen Coeliac Disease Research Centre, University 
      of Oslo, PO Box 4950 Nydalen, 0424, Oslo, Norway. c.wijmenga@umcg.nl.
FAU - Zhernakova, Alexandra
AU  - Zhernakova A
AD  - Department of Genetics, University of Groningen, University Medical Center 
      Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170427
PL  - England
TA  - Genome Biol
JT  - Genome biology
JID - 100960660
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoimmune Diseases/*genetics
MH  - Communicable Diseases/*genetics
MH  - Epistasis, Genetic
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - HLA Antigens/*genetics
MH  - Humans
PMC - PMC5406920
EDAT- 2017/04/30 06:00
MHDA- 2017/11/07 06:00
PMCR- 2017/04/27
CRDT- 2017/04/29 06:00
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2017/04/27 00:00 [pmc-release]
AID - 10.1186/s13059-017-1207-1 [pii]
AID - 1207 [pii]
AID - 10.1186/s13059-017-1207-1 [doi]
PST - epublish
SO  - Genome Biol. 2017 Apr 27;18(1):76. doi: 10.1186/s13059-017-1207-1.