PMID- 28450866
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Impact of Non-Human Leukocyte Antigen-Specific Antibodies in Kidney and Heart 
      Transplantation.
PG  - 434
LID - 10.3389/fimmu.2017.00434 [doi]
LID - 434
AB  - The presence of donor human leukocyte antigen (HLA)-specific antibodies has been 
      shown to be associated with graft loss and decreased patient survival, but it is 
      not uncommon that donor-specific HLA antibodies are absent in patients with 
      biopsy-proven antibody-mediated rejection. In this review, we focus on the latest 
      findings on antibodies against non-HLA antigens in kidney and heart 
      transplantation. These non-HLA antigens include myosin, vimentin, Kalpha1 tubulin, 
      collagen, and angiotensin II type 1 receptor. It is suggested that the 
      detrimental effects of HLA antibodies and non-HLA antibodies synergize together 
      to impact graft outcome. Injury of graft by HLA antibodies can cause the exposure 
      of neo-antigens which in turn stimulate the production of antibodies against 
      non-HLA antigens. On the other hand, the presence of non-HLA antibodies may 
      increase the risk for a patient to develop HLA-specific antibodies. These 
      findings indicate it is imperative to stratify the patient's immunologic risk by 
      assessing both HLA and non-HLA antibodies.
FAU - Zhang, Xiaohai
AU  - Zhang X
AD  - HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai 
      Medical Center, Los Angeles, CA, USA.
FAU - Reinsmoen, Nancy L
AU  - Reinsmoen NL
AD  - HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai 
      Medical Center, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170413
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5389972
OTO - NOTNLM
OT  - angiotensin II type 1 receptor antibody
OT  - heart transplant
OT  - human leukocyte antigen
OT  - kidney transplant
OT  - non-human leukocyte antigen antibody
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2017/01/01
CRDT- 2017/04/29 06:00
PHST- 2016/10/17 00:00 [received]
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.00434 [doi]
PST - epublish
SO  - Front Immunol. 2017 Apr 13;8:434. doi: 10.3389/fimmu.2017.00434. eCollection 
      2017.