PMID- 28450916 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 1792-0981 (Print) IS - 1792-1015 (Electronic) IS - 1792-0981 (Linking) VI - 13 IP - 3 DP - 2017 Mar TI - Exercise training on chronotropic response and exercise capacity in patients with type 2 diabetes mellitus. PG - 899-904 LID - 10.3892/etm.2017.4084 [doi] AB - The study was designed to observe the effects and relationship of exercise on chronotropic response (CR) and exercise capacity in patients with type 2 diabetes mellitus (T2DM). A total of 30 patients with T2DM underwent symptom-limited cardiopulmonary exercise testing (CPET) after excluding contraindication. For each subject individualized exercise prescription was formulated, and they received 12 weeks of exercise training after CPET retest to complete the comparison of CR indicators, including the ratio of maximum exercise heart rate to predicted maximum heart rate value (rHR), heart rate reserve rate (HRRes), heart rate recovery (HRR) of 1-6 min after exercise termination (HRR(1-6)), exercise capacity (peak VO(2)/kg) and other indicators. The results showed that after 12 weeks of exercise treatment, rHR, HRRes, HRR(1-6), and peak VO(2)/kg were significantly higher than before (P<0.05), with peak VO(2)/kg being positively correlated to rHR and HRRes (P<0.01). In conclusion, exercise training can improve cardiac dysfunction, abnormal HRR, enhance exercise capacity and adaptability of the cardiovascular system to exercise stress in T2DM patients. FAU - Jin, Li AU - Jin L AD - Department of Rehabilitation Medicine, Center Hospital of Xuzhou, Xuzhou, Jiangsu 221009, P.R. China. AD - Department of Cardiopulmonary Rehabilitation, Rehabilitation Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China. AD - Academy of Medical Technology, Medical College of Xuzhou, Xuzhou, Jiangsu 221004, P.R. China. FAU - Min, Gao AU - Min G AD - Department of Rehabilitation Medicine, Center Hospital of Xuzhou, Xuzhou, Jiangsu 221009, P.R. China. AD - Department of Cardiopulmonary Rehabilitation, Rehabilitation Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China. AD - Academy of Medical Technology, Medical College of Xuzhou, Xuzhou, Jiangsu 221004, P.R. China. FAU - Wei, Chen AU - Wei C AD - Department of Rehabilitation Medicine, Center Hospital of Xuzhou, Xuzhou, Jiangsu 221009, P.R. China. AD - Department of Cardiopulmonary Rehabilitation, Rehabilitation Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China. AD - Academy of Medical Technology, Medical College of Xuzhou, Xuzhou, Jiangsu 221004, P.R. China. FAU - Min, He AU - Min H AD - Department of Cardiopulmonary Rehabilitation, Rehabilitation Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China. FAU - Jie, Zhou AU - Jie Z AD - Academy of Medical Technology, Medical College of Xuzhou, Xuzhou, Jiangsu 221004, P.R. China. LA - eng PT - Journal Article DEP - 20170124 PL - Greece TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC5403443 OTO - NOTNLM OT - chronotropic response OT - exercise capacity OT - exercise training OT - heart rate recovery OT - type 2 diabetes mellitus EDAT- 2017/04/30 06:00 MHDA- 2017/04/30 06:01 PMCR- 2017/01/24 CRDT- 2017/04/29 06:00 PHST- 2016/06/29 00:00 [received] PHST- 2016/11/30 00:00 [accepted] PHST- 2017/04/29 06:00 [entrez] PHST- 2017/04/30 06:00 [pubmed] PHST- 2017/04/30 06:01 [medline] PHST- 2017/01/24 00:00 [pmc-release] AID - ETM-0-0-4084 [pii] AID - 10.3892/etm.2017.4084 [doi] PST - ppublish SO - Exp Ther Med. 2017 Mar;13(3):899-904. doi: 10.3892/etm.2017.4084. Epub 2017 Jan 24.