PMID- 28450950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 3
DP  - 2017 Mar
TI  - Efficacy and tolerability of once-daily 160 mg valsartan in Chinese patients with 
      mild to moderate hypertension.
PG  - 1109-1116
LID - 10.3892/etm.2017.4051 [doi]
AB  - The present multicentre, prospective, open-label, single treatment arm study 
      (Val-Perfect) examined the efficacy and tolerability of once-daily valsartan 
      monotherapy (80 mg for two weeks, followed by 160 mg for eight weeks) in 195 
      Chinese patients with mild to moderate hypertension, using office, home, and 
      ambulatory blood pressure (BP) monitoring. Significant mean reductions (P<0.0001) 
      were observed in office BP from baseline to week 10, with mean sitting systolic 
      BP (MSSBP) and mean sitting diastolic BP (MSDBP) values of 15.6+/-12.3 and 11.1+/-8.6 
      mmHg, respectively. The office BP control rate at week 10 was 56.9% (target 
      MSSBP/MSDBP <130/80 mmHg for patients with type 2 diabetes or chronic kidney 
      disease, <140/90 mmHg for others). Valsartan treatment significantly reduced mean 
      24-h SBP/DBP (-6.1/-4.4 mmHg; both P<0.0001) and mean home-monitored SBP/DBP 
      (-13.3/-9.1 mmHg; both P<0.0001) at week 10. The incidence of adverse events 
      (AEs) leading to discontinuation (1.5%) or drug-related AEs (3.1%) was low, with 
      no instances of mortality or drug-related serious AEs. These results indicate 
      that 160 mg valsartan is safe and effective at lowering BP in Chinese patients 
      with mild to moderate hypertension. The significant reductions in office-based 
      and out-of-office BP measures support the clinical relevance of moderate-dose 
      valsartan monotherapy for effective 24-h BP control.
FAU - Sun, Ningling
AU  - Sun N
AD  - Department of Cardiology, Peking University People's Hospital, Beijing 100044, 
      P.R. China.
FAU - Feng, Yingqing
AU  - Feng Y
AD  - Department of Cardiology, Guangdong General Hospital, Guangdong Cardiovascular 
      Institute, Guangzhou, Guangdong 510080, P.R. China.
FAU - Gao, Pingjin
AU  - Gao P
AD  - Department of Hypertension, Rui Jin Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai 200025, P.R. China.
FAU - Chen, Xiaoping
AU  - Chen X
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
FAU - Qi, Litong
AU  - Qi L
AD  - Department of Cardiology, Peking University First Hospital, Beijing 100034, P.R. 
      China.
FAU - Zhang, Shuyang
AU  - Zhang S
AD  - Department of Cardiology, Peking Union Medical College Hospital, Beijing 100730, 
      P.R. China.
FAU - Dong, Yugang
AU  - Dong Y
AD  - Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, Guangdong 510080, P.R. China.
FAU - Yang, Xinchun
AU  - Yang X
AD  - Department of Cardiology, Beijing Chao-yang Hospital, Capital Medical University, 
      Beijing 100020, P.R. China.
FAU - Li, Xinli
AU  - Li X
AD  - Department of Cardiology, The First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu 210029, P.R. China.
FAU - Chen, Yundai
AU  - Chen Y
AD  - Department of Cardiology, Academy of Military Medical Sciences, Beijing 100850, 
      P.R. China.
FAU - Liu, Lingli
AU  - Liu L
AD  - Medical Affairs, Novartis Pharmaceuticals, Beijing 100004, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170117
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5403463
OTO - NOTNLM
OT  - Val-Perfect
OT  - ambulatory blood pressure
OT  - home blood pressure
OT  - hypertension
OT  - office blood pressure
OT  - valsartan
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2017/01/17
CRDT- 2017/04/29 06:00
PHST- 2015/07/06 00:00 [received]
PHST- 2016/08/25 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2017/01/17 00:00 [pmc-release]
AID - ETM-0-0-4051 [pii]
AID - 10.3892/etm.2017.4051 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Mar;13(3):1109-1116. doi: 10.3892/etm.2017.4051. Epub 2017 Jan 
      17.