PMID- 28451387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 6
IP  - 3
DP  - 2017 Mar
TI  - Risperidone reverses the spatial object recognition impairment and hippocampal 
      BDNF-TrkB signalling system alterations induced by acute MK-801 treatment.
PG  - 285-290
LID - 10.3892/br.2017.850 [doi]
AB  - The aim of the present study was to investigate the effects of a commonly-used 
      atypical antipsychotic, risperidone, on alterations in spatial learning and in 
      the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase 
      B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) 
      treatment. In experiment 1, adult male Sprague-Dawley rats subjected to acute 
      treatment of either low-dose MK801 (0.1 mg/kg) or normal saline (vehicle) were 
      tested for spatial object recognition and hippocampal expression levels of BDNF, 
      TrkB and the phophorylation of TrkB (p-TrkB). We found that compared to the 
      vehicle, MK-801 treatment impaired spatial object recognition of animals and 
      downregulated the expression levels of p-TrkB. In experiment 2, MK-801- or 
      vehicle-treated animals were further injected with risperidone (0.1 mg/kg) or 
      vehicle before behavioural testing and sacrifice. Of note, we found that 
      risperidone successfully reversed the deleterious effects of MK-801 on spatial 
      object recognition and upregulated the hippocampal BDNF-TrkB signalling system. 
      Collectively, the findings suggest that cognitive deficits from acute 
      N-methyl-D-aspartate receptor blockade may be associated with the hypofunction of 
      hippocampal BDNF-TrkB signalling system and that risperidone was able to reverse 
      these alterations.
FAU - Chen, Guangdong
AU  - Chen G
AD  - Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Lin, Xiaodong
AU  - Lin X
AD  - Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Li, Gongying
AU  - Li G
AD  - College of Psychiatry, Jining Medical University, Jining, Shandong 272119, P.R. 
      China.
FAU - Jiang, Diego
AU  - Jiang D
AD  - Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 
      325000, P.R. China.
FAU - Lib, Zhiruo
AU  - Lib Z
AD  - College of Psychiatry, Jining Medical University, Jining, Shandong 272119, P.R. 
      China.
FAU - Jiang, Ronghuan
AU  - Jiang R
AD  - Department of Psychological Medicine, Chinese PLA (People's Liberation Army) 
      Medical School, Beijing 100853, P.R. China.
FAU - Zhuo, Chuanjun
AU  - Zhuo C
AD  - Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 
      325000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170127
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC5403402
OTO - NOTNLM
OT  - atypical antipsychotics
OT  - brain-derived neurotrophic factor
OT  - dizocilpine maleate
OT  - schizophrenia
OT  - spatial object recognition
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2017/01/27
CRDT- 2017/04/29 06:00
PHST- 2016/08/08 00:00 [received]
PHST- 2017/01/24 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2017/01/27 00:00 [pmc-release]
AID - BR-0-0-850 [pii]
AID - 10.3892/br.2017.850 [doi]
PST - ppublish
SO  - Biomed Rep. 2017 Mar;6(3):285-290. doi: 10.3892/br.2017.850. Epub 2017 Jan 27.