PMID- 28451457
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2056-4538 (Print)
IS  - 2056-4538 (Electronic)
IS  - 2056-4538 (Linking)
VI  - 3
IP  - 2
DP  - 2017 Apr
TI  - Fluorescence in situ hybridization in surgical pathology: principles and 
      applications.
PG  - 73-99
LID - 10.1002/cjp2.64 [doi]
AB  - Identification of recurrent tumour-specific chromosomal translocations and novel 
      fusion oncogenes has important diagnostic, therapeutic and prognostic 
      implications. Over the past decade, fluorescence in situ hybridization (FISH) 
      analysis of tumour samples has been one of the most rapidly growing areas in 
      genomic medicine and surgical pathology practice. Unlike traditional 
      cytogenetics, FISH affords a rapid analysis of formalin-fixed, paraffin-embedded 
      cells within a routine pathology practice workflow. As more diagnostic and 
      treatment decisions are based on results of FISH, demand for the technology will 
      become more widespread. Common FISH-detected alterations are chromosome 
      deletions, gains, translocations, amplifications and polysomy. These chromosome 
      alterations may have diagnostic and therapeutic implications for many tumour 
      types. Integrating genomic testing into cancer treatment decisions poses many 
      technical challenges, but rapid progress is being made to overcome these 
      challenges in precision medicine. FISH assessment of chromosomal changes relevant 
      to differential diagnosis and cancer treatment decisions has become an important 
      tool for the surgical pathologist. The aim of this review is to provide a 
      theoretical and practical survey of FISH detected translocations with a focus on 
      strategies for clinical application in surgical pathology practice.
FAU - Cheng, Liang
AU  - Cheng L
AD  - Department of Pathology and Laboratory MedicineIndiana University School of 
      MedicineIndianapolisINUSA.
AD  - Department of UrologyIndiana University School of MedicineIndianapolisINUSA.
FAU - Zhang, Shaobo
AU  - Zhang S
AD  - Department of Pathology and Laboratory MedicineIndiana University School of 
      MedicineIndianapolisINUSA.
FAU - Wang, Lisha
AU  - Wang L
AD  - Michigan Center for Translational PathologyUniversity of MichiganAnn ArborMIUSA.
FAU - MacLennan, Gregory T
AU  - MacLennan GT
AD  - Departments of Pathology and Laboratory MedicineCase Western Reserve 
      UniversityClevelandOHUSA.
FAU - Davidson, Darrell D
AU  - Davidson DD
AD  - Department of Pathology and Laboratory MedicineIndiana University School of 
      MedicineIndianapolisINUSA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170223
PL  - England
TA  - J Pathol Clin Res
JT  - The journal of pathology. Clinical research
JID - 101658534
PMC - PMC5402181
OTO - NOTNLM
OT  - differential diagnosis
OT  - fluorescence in situ hybridization
OT  - molecular genetics/cytogenetics
OT  - precision medicine
OT  - targeted therapy
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2017/02/23
CRDT- 2017/04/29 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2016/12/16 00:00 [revised]
PHST- 2016/12/20 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2017/02/23 00:00 [pmc-release]
AID - CJP264 [pii]
AID - 10.1002/cjp2.64 [doi]
PST - epublish
SO  - J Pathol Clin Res. 2017 Feb 23;3(2):73-99. doi: 10.1002/cjp2.64. eCollection 2017 
      Apr.