PMID- 28451885 OWN - NLM STAT- MEDLINE DCOM- 20190211 LR - 20190215 IS - 1559-1182 (Electronic) IS - 0893-7648 (Linking) VI - 55 IP - 4 DP - 2018 Apr TI - Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats. PG - 2740-2753 LID - 10.1007/s12035-017-0538-y [doi] AB - During development, the brain goes through fundamental processes, including organization of neural networks and plasticity. Environmental interventions may change initial brain programming, leading to long-lasting effects and altering the susceptibility to psychopathologies, including depression disorder. It is known that depression is a psychiatric disorder with a high prevalence worldwide, including high rates among adolescents. In this study, we evaluated whether social isolation in the prepubertal period and chronic use of high-fat diet (HFD) may induce depressive-like behavior in male adult rats. We also investigated hippocampal plasticity markers and neurotransmitter systems. We found both social isolation and HFD induced a depressive-like behavior in the forced swimming task. Moreover, chronic HFD reduced synaptic markers in hippocampus, demonstrated by reductions in betaIII-tubulin (neuronal marker), PSD-95, SNAP-25, and neurotrophin-3. The HFD group also presented decreased glutamatergic and GABAergic receptors subunits. On the other hand, stress affected hippocampal brain-derived neurotrophic factor (BDNF) signaling pathways, and increased expression of subunit of the NMDA receptor (NR2A). Both factors (stress and diet) decreased GR in the hippocampus without affecting plasma corticosterone at basal levels. Interactions between early stress and HFD access were observed only in the BNDF receptor (tropomyosin receptor kinase B; TrkB) and synaptophysin. In summary, these findings showed that a brief social isolation and chronic HFD, during a sensitive developmental period, cause depressive-like behavior in adulthood. The mechanisms underlying these behavioral effects may involve changes in the levels of synaptic proteins in hippocampus: HFD consumption appears to affect synaptic markers, while social isolation affected BDNF signaling more significantly. FAU - Arcego, Danusa Mar AU - Arcego DM AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. danusa.arcego@gmail.com. AD - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil. danusa.arcego@gmail.com. FAU - Toniazzo, Ana Paula AU - Toniazzo AP AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Krolow, Rachel AU - Krolow R AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Lampert, Carine AU - Lampert C AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Berlitz, Carolina AU - Berlitz C AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Dos Santos Garcia, Emily AU - Dos Santos Garcia E AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - do Couto Nicola, Fabricio AU - do Couto Nicola F AD - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil. FAU - Hoppe, Juliana Bender AU - Hoppe JB AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Gaelzer, Mariana Maier AU - Gaelzer MM AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Klein, Caroline Peres AU - Klein CP AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. FAU - Lazzaretti, Camilla AU - Lazzaretti C AD - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil. FAU - Dalmaz, Carla AU - Dalmaz C AD - Programa de Pos-Graduacao em Ciencias Biologicas: Bioquimica/Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Ramiro Barcelos, 2600 (Anexo) Lab. 37., Porto Alegre, RS, 90035-003, Brazil. AD - Programa de Pos-Graduacao em Neurociencias, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil. LA - eng PT - Journal Article DEP - 20170427 PL - United States TA - Mol Neurobiol JT - Molecular neurobiology JID - 8900963 RN - 0 (Biomarkers) RN - 0 (Receptors, Glucocorticoid) RN - 3KX376GY7L (Glutamic Acid) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - 57-50-1 (Sucrose) SB - IM MH - Animals MH - *Behavior, Animal MH - Biomarkers/metabolism MH - Depression/*etiology/*physiopathology/psychology MH - Diet, High-Fat MH - Glutamic Acid/metabolism MH - Hippocampus/pathology/*physiopathology MH - Male MH - Models, Biological MH - *Neuronal Plasticity MH - Rats, Wistar MH - Receptors, Glucocorticoid/metabolism MH - Sexual Maturation MH - Social Isolation/psychology MH - Stress, Psychological/*complications MH - Sucrose MH - gamma-Aminobutyric Acid/metabolism OTO - NOTNLM OT - BDNF OT - Early life environment OT - Emotional responses OT - High-calorie diets OT - Prepubertal period OT - Social isolation EDAT- 2017/04/30 06:00 MHDA- 2019/02/12 06:00 CRDT- 2017/04/29 06:00 PHST- 2017/02/14 00:00 [received] PHST- 2017/04/07 00:00 [accepted] PHST- 2017/04/30 06:00 [pubmed] PHST- 2019/02/12 06:00 [medline] PHST- 2017/04/29 06:00 [entrez] AID - 10.1007/s12035-017-0538-y [pii] AID - 10.1007/s12035-017-0538-y [doi] PST - ppublish SO - Mol Neurobiol. 2018 Apr;55(4):2740-2753. doi: 10.1007/s12035-017-0538-y. Epub 2017 Apr 27.