PMID- 28451958
OWN - NLM
STAT- MEDLINE
DCOM- 20170622
LR  - 20181202
IS  - 1573-2959 (Electronic)
IS  - 0167-6369 (Linking)
VI  - 189
IP  - 5
DP  - 2017 May
TI  - Residue and intake risk assessment of prothioconazole and its metabolite 
      prothioconazole-desthio in wheat field.
PG  - 236
LID - 10.1007/s10661-017-5943-1 [doi]
AB  - In the environment, plants and animals in vivo, pesticides can be degraded or 
      metabolized to form transformation products (TPs) or metabolites, which are even 
      more toxic than parent pesticides. Hence, it was necessary to evaluate residue 
      and risk of pesticides and their TPs (or metabolites). Here, a rapid, simple, and 
      reliable method using QuEChERS and LC-MS/MS had been developed for simultaneous 
      analysis of prothioconazole and its toxic metabolite, prothioconazole-desthio, in 
      soil, wheat plant, straw, and grain. The average recoveries of prothioconazole 
      and prothioconazole-desthio in four matrices ranged from 86 to 108% with relative 
      standard deviations (RSDs) of 0.53-11.87% at three spiking levels. The method was 
      successfully applied to investigate the dissipation and terminal residues of the 
      two compounds in wheat field. It was shown that prothioconazole was rapidly 
      degraded to prothioconazole-desthio, with half-lives below 5.82 days. 
      Prothioconazole-desthio was slowly dissipated in soil and plant. The terminal 
      residues of prothioconazole in wheat grain with a pre-harvest interval (PHI) of 
      21 or 28 days were below the maximum residue limits (MRLs) (0.1 mg/kg, Codex 
      Alimentarius Commission (CAC)). We also evaluated the intake risk of 
      prothioconazole-desthio residues in wheat grain in China. For long-term intake 
      assessment, the hazard quotients (HQ) ranged from 1.30 to 5.95%. For short-term 
      intake assessment, the acute hazard indexes (aHI) ranged from 1.94 to 18.2%. It 
      indicated that the intake risk of prothioconazole-desthio in wheat consumption 
      was acceptable. Thus, the prothioconazole application on wheat with the 
      scientific practices would not pose public health risk.
FAU - Lin, HongFang
AU  - Lin H
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, 30 Xueyuan Road, Haidian District, Beijing, 100083, People's Republic of 
      China.
FAU - Dong, Bizhang
AU  - Dong B
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, 30 Xueyuan Road, Haidian District, Beijing, 100083, People's Republic of 
      China.
FAU - Hu, JiYe
AU  - Hu J
AD  - Laboratory of Pesticide Residues and Environmental Toxicology, School of 
      Chemistry and Biological Engineering, University of Science and Technology 
      Beijing, 30 Xueyuan Road, Haidian District, Beijing, 100083, People's Republic of 
      China. jyhu@ustb.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170427
PL  - Netherlands
TA  - Environ Monit Assess
JT  - Environmental monitoring and assessment
JID - 8508350
RN  - 0 (Pesticide Residues)
RN  - 0 (Pesticides)
RN  - 0 (Soil)
RN  - 0 (Soil Pollutants)
RN  - 0 (Triazoles)
RN  - 27B9FV58IY (prothioconazole)
SB  - IM
MH  - China
MH  - Chromatography, Liquid
MH  - Environmental Monitoring/*methods
MH  - Half-Life
MH  - Pesticide Residues/*analysis
MH  - Pesticides/analysis
MH  - Risk Assessment
MH  - Soil/chemistry
MH  - Soil Pollutants/*analysis
MH  - Tandem Mass Spectrometry/methods
MH  - Triazoles/*analysis
MH  - Triticum/chemistry
OTO - NOTNLM
OT  - Intake risk
OT  - Prothioconazole
OT  - Prothioconazole-desthio
OT  - Residue
OT  - Wheat field
EDAT- 2017/04/30 06:00
MHDA- 2017/06/24 06:00
CRDT- 2017/04/29 06:00
PHST- 2016/11/08 00:00 [received]
PHST- 2017/04/07 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
AID - 10.1007/s10661-017-5943-1 [pii]
AID - 10.1007/s10661-017-5943-1 [doi]
PST - ppublish
SO  - Environ Monit Assess. 2017 May;189(5):236. doi: 10.1007/s10661-017-5943-1. Epub 
      2017 Apr 27.