PMID- 28452951
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20181113
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 5
DP  - 2017 Apr 28
TI  - Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models.
LID - 10.3390/ijms18050932 [doi]
LID - 932
AB  - The newly identified smoke hazard, thirdhand smoke (THS), has gained public 
      attention in recent years but its health impact and biological effects are 
      largely unknown. THS may be defined by "the four Rs": tobacco chemicals that 
      remain, react, re-emit, and/or are resuspended long after active smoking has 
      ceased. This review summarizes recent research progress in the effects of THS on 
      genotoxicity, metabolism and early life development using cellular and animal 
      models. We first reported that THS generated in laboratory systems caused 
      significant DNA damage in human cell lines. Our finding that THS significantly 
      induces oxidative base lesions has been confirmed in skin wounds of mice models 
      exposed to THS. THS also induced metabolomic changes in human reproductive cell 
      lines. Furthermore, we demonstrated that early exposure to THS not only 
      negatively impacts body weight in both male and female mice, but also induces 
      persistent changes to immunological parameters in peripheral blood in these mice. 
      These results indicate that THS is genotoxic at realistic experimental doses and 
      that there may be a window of susceptibility for some forms of cellular damage 
      induced by THS.
FAU - Hang, Bo
AU  - Hang B
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. bo_hang@lbl.gov.
FAU - Wang, Pin
AU  - Wang P
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. pinwang@lbl.gov.
AD  - Department of Gastroenterology, Drum Tower Clinical Medical School of Nanjing 
      Medical University, Nanjing 210008, China. pinwang@lbl.gov.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. yuezhao@lbl.gov.
FAU - Sarker, Altaf
AU  - Sarker A
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. ahsarker@lbl.gov.
FAU - Chenna, Ahmed
AU  - Chenna A
AD  - LabCorp Specialty Testing Group, Monogram Biosciences Inc., South San Francisco, 
      CA 94080, USA. a_chenna@yahoo.com.
FAU - Xia, Yankai
AU  - Xia Y
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 
      Medical University, Nanjing 211166, China. yankaixia@njmu.edu.cn.
FAU - Snijders, Antoine M
AU  - Snijders AM
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. AMSnijders@lbl.gov.
FAU - Mao, Jian-Hua
AU  - Mao JH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, USA. jhmao@lbl.gov.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170428
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Air Pollutants)
RN  - 0 (DNA Adducts)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Air Pollutants/toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - DNA Adducts/chemistry/metabolism
MH  - DNA Damage/drug effects
MH  - Humans
MH  - Immune System/drug effects/metabolism
MH  - Models, Animal
MH  - Reproduction/drug effects
MH  - *Tobacco Smoke Pollution
PMC - PMC5454845
OTO - NOTNLM
OT  - DNA adducts
OT  - DNA damage
OT  - DNA strand breaks
OT  - animal studies
OT  - early exposure
OT  - genotoxicity
OT  - health impact
OT  - secondhand smoke
OT  - thirdhand smoke
OT  - tobacco control
COIS- The authors declare no conflict of interest.
EDAT- 2017/04/30 06:00
MHDA- 2018/01/23 06:00
PMCR- 2017/05/01
CRDT- 2017/04/29 06:00
PHST- 2017/03/13 00:00 [received]
PHST- 2017/04/18 00:00 [revised]
PHST- 2017/04/24 00:00 [accepted]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - ijms18050932 [pii]
AID - ijms-18-00932 [pii]
AID - 10.3390/ijms18050932 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Apr 28;18(5):932. doi: 10.3390/ijms18050932.