PMID- 28453306
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20180320
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 14
IP  - 3
DP  - 2017 Jun
TI  - The Association of Lung Clearance Index with COPD and FEV(1) Reduction in 'Men 
      Born in 1914'.
PG  - 324-329
LID - 10.1080/15412555.2017.1314455 [doi]
AB  - Lung Clearance Index (LCI) provides an overall measurement of ventilation 
      inhomogeneity. This population-based study examines whether LCI predicts 
      pulmonary obstruction and incidence of chronic obstructive pulmonary disease 
      (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and 
      spirometry were performed in 674 men from the cohort "Men born in 1914" at age 
      55 years. Subjects were classified into quartiles (Q) of LCI and according to LCI 
      above and below upper limit of normal (ULN). Incidence of COPD events (COPD 
      hospitalisations or COPD-related deaths) were monitored over the remaining life 
      span of the men, by linkage with national hospital registers. In addition, 
      development of pulmonary obstruction (i.e., FEV(1)/vital capacity below lower 
      limit of normal (LLN)) was studied in 387 men who were re-examined with 
      spirometry at 68 years of age. Over 44 years of follow-up, there were 85 incident 
      COPD events. Hazards ratios (HRs) for COPD across quartiles of LCI were: Q1 1.00 
      (reference), Q2 1.30 (95% confidence interval: 0.61-2.74), Q3 1.97 (0.97-3.98) 
      and Q4 3.99 (2.06-7.71) (p value for trend <0.001). This relationship remained 
      significant after adjustments for confounding factors, including smoking and 
      FEV(1) (HR, Q4 vs Q1: 2.34 (1.17-4.69); p value for trend: 0.006). Reduction of 
      FEV(1) between 55 and 68 years of age and incidence of pulmonary obstruction was 
      highest in those with high LCI. High LCI is associated with future development of 
      pulmonary obstruction and incidence of COPD hospitalisations in men from the 
      general population.
FAU - Zaigham, Suneela
AU  - Zaigham S
AD  - a Department of Clinical Sciences Malmo , Lund University , Malmo , Sweden.
FAU - Wollmer, Per
AU  - Wollmer P
AD  - b Department of Translational Medicine , Lund University , Malmo , Sweden.
FAU - Engstrom, Gunnar
AU  - Engstrom G
AD  - a Department of Clinical Sciences Malmo , Lund University , Malmo , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170428
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Airway Obstruction/*epidemiology
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*epidemiology/mortality/*physiopathology
MH  - Spirometry
MH  - Sweden/epidemiology
MH  - Time Factors
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease
OT  - incidence
OT  - lung clearance index
OT  - spirometry
EDAT- 2017/04/30 06:00
MHDA- 2018/03/21 06:00
CRDT- 2017/04/29 06:00
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2017/04/29 06:00 [entrez]
AID - 10.1080/15412555.2017.1314455 [doi]
PST - ppublish
SO  - COPD. 2017 Jun;14(3):324-329. doi: 10.1080/15412555.2017.1314455. Epub 2017 Apr 
      28.