PMID- 28453487
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20181113
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 58
IP  - 3
DP  - 2017
TI  - Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving 
      Decline: Brief Report.
PG  - 675-680
LID - 10.3233/JAD-170067 [doi]
AB  - We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal 
      fluid (CSF) biomarkers (amyloid-beta42 [Abeta42], tau, phosphorylated tau181 [ptau181], 
      tau/Abeta42, and ptau181/Abeta42) of Alzheimer's disease pathology to predict driving 
      decline among cognitively-normal older adults (N = 116) aged >/=65. Cox 
      proportional hazards models examined time to receiving a rating of marginal or 
      fail on the driving test. Age, education, and gender were adjusted in the models. 
      Participants with more abnormal CSF (Abeta42, tau/Abeta42, ptau181/Abeta42) and NPS were 
      faster to receive a marginal/fail on the road test compared to those without NPS. 
      NPS interact with abnormal CSF biomarkers to impact driving performance among 
      cognitively-normal older adults.
FAU - Babulal, Ganesh M
AU  - Babulal GM
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Stout, Sarah H
AU  - Stout SH
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Head, Denise
AU  - Head D
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Psychological and Brain Sciences, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Radiology, Washington University School of Medicine, St. Louis, MO, 
      USA.
FAU - Holtzman, David M
AU  - Holtzman DM
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
AD  - Hope Center for Neurological Disorders, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Fagan, Anne M
AU  - Fagan AM
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
AD  - Hope Center for Neurological Disorders, Washington University School of Medicine, 
      St. Louis, MO, USA.
FAU - Morris, John C
AU  - Morris JC
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
AD  - Hope Center for Neurological Disorders, Washington University School of Medicine, 
      St. Louis, MO, USA.
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St. Louis, MO, USA.
AD  - Department of Physical Therapy, Washington University School of Medicine, St. 
      Louis, MO, USA.
AD  - Department of Occupational Therapy, Washington University School of Medicine, St. 
      Louis, MO, USA.
FAU - Roe, Catherine M
AU  - Roe CM
AD  - Knight Alzheimer's Disease Research Center, Washington University School of 
      Medicine, St. Louis, MO, USA.
AD  - Department of Neurology, Washington University School of Medicine, St. Louis, MO, 
      USA.
LA  - eng
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P01 AG026276/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
GR  - R01 AG043434/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (MAPT protein, human)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
SB  - IM
MH  - Affect
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*cerebrospinal fluid/*psychology
MH  - Amyloid beta-Peptides/*cerebrospinal fluid
MH  - Automobile Driving
MH  - Biomarkers/cerebrospinal fluid
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Longitudinal Studies
MH  - Male
MH  - Peptide Fragments/*cerebrospinal fluid
MH  - Phosphorylation
MH  - Proportional Hazards Models
MH  - tau Proteins/*cerebrospinal fluid
PMC - PMC5555740
MID - NIHMS872792
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cerebrospinal fluid
OT  - depression
OT  - neuropsychology
OT  - noncognitive outcomes
OT  - preclinical
EDAT- 2017/04/30 06:00
MHDA- 2018/03/22 06:00
PMCR- 2018/01/01
CRDT- 2017/04/29 06:00
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/04/29 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - JAD170067 [pii]
AID - 10.3233/JAD-170067 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;58(3):675-680. doi: 10.3233/JAD-170067.