PMID- 28453607
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20171002
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 186
IP  - 1
DP  - 2017 Jul 1
TI  - Determining the Best Strategies for Maternally Targeted Pertussis Vaccination 
      Using an Individual-Based Model.
PG  - 109-117
LID - 10.1093/aje/kwx002 [doi]
AB  - Rising pertussis incidence has prompted a number of countries to implement 
      maternally targeted vaccination strategies to protect vulnerable infants, but 
      questions remain about the optimal design of such strategies. We simulated 
      pertussis transmission within an individual-based model parameterized to match 
      Australian conditions, explicitly linking infants and their mothers to estimate 
      the effectiveness of alternative maternally targeted vaccination strategies 
      (antenatal delivery vs. postnatal delivery) and the benefit of revaccination over 
      the course of multiple pregnancies. For firstborn infants aged less than 2 
      months, antenatal immunization reduced annual pertussis incidence by 60%, from 
      780 per 100,000 firstborn children under age 2 months (interquartile range (IQR), 
      682-862) to 315 per 100,000 (IQR, 260-370), while postnatal vaccination produced 
      a minimal reduction, with an incidence of 728 per 100,000 (IQR, 628-789). 
      Subsequent infants obtained limited protection from a single antenatal dose, but 
      revaccinating mothers during every pregnancy decreased incidence for these 
      infants by 58%, from 1,878 per 100,000 subsequent children under age 2 months 
      (IQR, 1,712-2,076) to 791 per 100,000 (IQR, 683-915). Subsequent infants also 
      benefited from household-level herd immunity when antenatal vaccination for every 
      pregnancy was combined with a toddler booster dose at age 18 months; incidence 
      was reduced to 626 per 100,000 (IQR, 548-691). Our approach provides useful 
      information to aid consideration of alternative maternally targeted vaccination 
      strategies and can inform development of outcome measures for program evaluation.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of the Johns 
      Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Campbell, Patricia Therese
AU  - Campbell PT
FAU - McVernon, Jodie
AU  - McVernon J
FAU - Geard, Nicholas
AU  - Geard N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Pertussis Vaccine)
SB  - IM
MH  - Age Factors
MH  - Australia/epidemiology
MH  - Child, Preschool
MH  - Computer Simulation
MH  - Drug Administration Schedule
MH  - Family Characteristics
MH  - Female
MH  - Humans
MH  - Immunization, Secondary
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pertussis Vaccine/*administration & dosage/immunology
MH  - Pregnancy
MH  - Sex Factors
MH  - Whooping Cough/*epidemiology/*prevention & control
OTO - NOTNLM
OT  - computer simulation
OT  - disease transmission
OT  - immunity
OT  - infectiousness
OT  - maternally acquired immunity
OT  - pertussis vaccine
OT  - population dynamics
OT  - whooping cough
EDAT- 2017/04/30 06:00
MHDA- 2017/10/03 06:00
CRDT- 2017/04/29 06:00
PHST- 2015/07/06 00:00 [received]
PHST- 2016/07/08 00:00 [accepted]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2017/04/29 06:00 [entrez]
AID - 3769267 [pii]
AID - 10.1093/aje/kwx002 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2017 Jul 1;186(1):109-117. doi: 10.1093/aje/kwx002.